REO is a joint project of the Inria Research Center of Paris-Rocquencourt and the Jacques-Louis Lions Laboratory (LJLL) of the Pierre and Marie Curie University (Paris 6) and CNRS (UMR7598). Its research activities are aimed at

modeling some aspects of the cardiovascular and respiratory systems, both in normal and pathological states;

developing and analyzing efficient, robust and reliable numerical methods for the simulation of those models;

developing simulation software to guide medical decision and to design more efficient medical devices.

In large vessels and in large bronchi, blood and air flows are generally supposed to be governed by the incompressible Navier-Stokes equations. Indeed in large arteries, blood can be supposed to be Newtonian, and at rest air can be modeled as an incompressible fluid. The cornerstone of the simulations is therefore a Navier-Stokes solver. But other physical features have also to be taken into account in simulations of biological flows, in particular fluid-structure interaction in large vessels and transport of sprays, particles or chemical species.

Fluid-structure coupling occurs both in the respiratory and in the circulatory systems. We focus mainly on blood flows since our work is more advanced in this field. But the methods developed for blood flows could be also applied to the respiratory system.

Here “fluid-structure interaction” means a coupling between the 3D Navier-Stokes equations and a 3D (possibly thin) structure in large displacements.

The numerical simulations of the interaction between the artery wall and the blood flows raise many issues: (1) the displacement of the wall cannot be supposed to be infinitesimal, geometrical nonlinearities are therefore present in the structure and the fluid problem have to be solved on a moving domain (2) the densities of the artery walls and the blood being close, the coupling is strong and has to be tackled very carefully to avoid numerical instabilities, (3) “naive” boundary conditions on the artificial boundaries induce spurious reflection phenomena.

Simulation of valves, either at the outflow of the cardiac chambers or in veins, is another example of difficult fluid-structure problems arising in blood flows. In addition, very large displacements and changes of topology (contact problems) have to be handled in those cases.

Due to stability reasons, it seems impossible to successfully apply in hemodynamics the explicit coupling schemes used in other fluid-structure problems, like aeroelasticity. As a result, fluid-structure interaction in biological flows raise new challenging issues in scientific computing and numerical analysis : new schemes have to be developed and analyzed.

We have proposed and analyzed over the last few years several efficient fluid-structure interaction algorithms. This topic remains very active. We are now using these algorithms to address inverse problems in blood flows to make patient specific simulations (for example, estimation of artery wall stiffness from medical imaging).

Complex two-phase fluids can be modeled in many different ways. Eulerian models describe both phases by physical quantities such as the density, velocity or energy of each phase. In the mixed fluid-kinetic models, the biphasic fluid has one dispersed phase, which is constituted by a spray of droplets, with a possibly variable size, and a continuous classical fluid.

This type of model was first introduced by Williams
in the frame of combustion. It was later used to develop the Kiva
code at the Los Alamos National Laboratory, or the
Hesione code , for example. It has a wide range of
applications, besides the nuclear setting: diesel engines, rocket
engines , therapeutic sprays, *etc.* One of the
interests of such a model is that various phenomena on the
droplets can be taken into account with an accurate precision:
collision, breakups, coagulation, vaporization, chemical reactions,
*etc.*, at the level of the droplets.

The model usually consists in coupling a kinetic equation, that describes the spray through a probability density function, and classical fluid equations (typically Navier-Stokes). The numerical solution of this system relies on the coupling of a method for the fluid equations (for instance, a finite volume method) with a method fitted to the spray (particle method, Monte Carlo).

We are mainly interested in modeling therapeutic sprays either for local or general treatments. The study of the underlying kinetic equations should lead us to a global model of the ambient fluid and the droplets, with some mathematical significance. Well-chosen numerical methods can give some tracks on the solutions behavior and help to fit the physical parameters which appear in the models.

Multiscale modeling is a necessary step for blood and respiratory flows. In this section, we focus on blood flows. Nevertheless, similar investigations are currently carried out on respiratory flows.

Problems arising in the numerical modeling of the human cardiovascular
system often require an accurate description of the flow in a specific
sensible subregion (carotid bifurcation, stented artery, *etc.*).
The description of such local phenomena is better addressed by means
of three-dimensional (3D) simulations, based on the numerical
approximation of the incompressible Navier-Stokes equations, possibly
accounting for compliant (moving) boundaries. These simulations
require the specification of boundary data on artificial boundaries
that have to be introduced to delimit the vascular district under
study. The definition of such boundary conditions is critical and, in
fact, influenced by the global systemic dynamics. Whenever the
boundary data is not available from accurate measurements, a proper
boundary condition requires a mathematical description of the action
of the reminder of the circulatory system on the local district. From
the computational point of view, it is not affordable to describe the
whole circulatory system keeping the same level of detail. Therefore,
this mathematical description relies on simpler models, leading to the
concept of *geometrical multiscale* modeling of the circulation
. The underlying idea consists in coupling
different models (3D, 1D or 0D) with a decreasing level of accuracy,
which is compensated by their decreasing level of computational
complexity.

The research on this topic aims at providing a correct methodology and a mathematical and numerical framework for the simulation of blood flow in the whole cardiovascular system by means of a geometric multiscale approach. In particular, one of the main issues will be the definition of stable coupling strategies between 3D and reduced order models.

To model the arterial tree, a standard way consists of imposing a
pressure or a flow rate at the inlet of the aorta, *i.e.* at the
network entry. This strategy does not allow to describe important
features as the overload in the heart caused by backward traveling
waves. Indeed imposing a boundary condition at the beginning of the
aorta artificially disturbs physiological pressure waves going from
the arterial tree to the heart. The only way to catch this
physiological behavior is to couple the arteries with a model of
heart, or at least a model of left ventricle.

A constitutive law for the myocardium, controlled by an electrical
command, has been developed in the CardioSense3D project

A long term goal is to achieve 3D simulations of a system including heart and arteries. One of the difficulties of this very challenging task is to model the cardiac valves. To this purpose, we investigate a mix of arbitrary Lagrangian Eulerian and fictitious domain approaches or x-fem strategies, or simplified valve models based on an immersed surface strategy.

The heart is the organ that regulates, through its periodical contraction, the distribution of oxygenated blood in human vessels in order to nourish the different parts of the body. The heart needs its own supply of blood to work. The coronary arteries are the vessels that accomplish this task. The phenomenon by which blood reaches myocardial heart tissue starting from the blood vessels is called in medicine perfusion. The analysis of heart perfusion is an interesting and challenging problem. Our aim is to perform a three-dimensional dynamical numerical simulation of perfusion in the beating heart, in order to better understand the phenomena linked to perfusion. In particular the role of the ventricle contraction on the perfusion of the heart is investigated as well as the influence of blood on the solid mechanics of the ventricle. Heart perfusion in fact implies the interaction between heart muscle and blood vessels, in a sponge-like material that contracts at every heartbeat via the myocardium fibers.

Despite recent advances on the anatomical description and measurements of the coronary tree and on the corresponding physiological, physical and numerical modeling aspects, the complete modeling and simulation of blood flows inside the large and the many small vessels feeding the heart is still out of reach. Therefore, in order to model blood perfusion in the cardiac tissue, we must limit the description of the detailed flows at a given space scale, and simplify the modeling of the smaller scale flows by aggregating these phenomena into macroscopic quantities, by some kind of “homogenization” procedure. To that purpose, the modeling of the fluid-solid coupling within the framework of porous media appears appropriate.

Poromechanics is a simplified mixture theory where a complex
fluid-structure interaction problem is replaced by a superposition of
both components, each of them representing a fraction of the complete
material at every point. It originally emerged in soils mechanics with
the work of Terzaghi , and Biot later
gave a description of the mechanical behavior of a porous medium using
an elastic formulation for the solid matrix, and Darcy's law for the
fluid flow through the matrix. Finite strain poroelastic models have
been proposed (see references in ), albeit with *ad hoc* formulations for which compatibility with thermodynamics laws and incompressibility conditions is not established.

The same way the myocardium needs to be perfused for the heart to beat, when it has reached a certain size, tumor tissue needs to be perfused by enough blood to grow. It thus triggers the creation of new blood vessels (angiogenesis) to continue to grow. The interaction of tumor and its micro-environment is an active field of research. One of the challenges is that phenomena (tumor cell proliferation and death, blood vessel adaptation, nutrient transport and diffusion, etc) occur at different scales. A multi-scale approach is thus being developed to tackle this issue. The long term objective is to predict the efficiency of drugs and optimize therapy of cancer.

We aim at developing a multiscale model of the respiratory tract. Intraprenchymal airways distal from generation 7 of the tracheabronchial tree (TBT), which cannot be visualized by common medical imaging techniques, are modeled either by a single simple model or by a model set according to their order in TBT. The single model is based on straight pipe fully developed flow (Poiseuille flow in steady regimes) with given alveolar pressure at the end of each compartment. It will provide boundary conditions at the bronchial ends of 3D TBT reconstructed from imaging data. The model set includes three serial models. The generation down to the pulmonary lobule will be modeled by reduced basis elements. The lobular airways will be represented by a fractal homogenization approach. The alveoli, which are the gas exchange loci between blood and inhaled air, inflating during inspiration and deflating during expiration, will be described by multiphysics homogenization.

Cardiovascular diseases like atherosclerosis or aneurysms are a major cause of mortality. It is generally admitted that a better knowledge of local flow patterns could improve the treatment of these pathologies (although many other biophysical phenomena obviously take place in the development of such diseases). In particular, it has been known for years that the association of low wall shear stress and high oscillatory shear index give relevant indications to localize possible zones of atherosclerosis. It is also known that medical devices (graft or stent) perturb blood flows and may create local stresses favorable with atherogenesis. Numerical simulations of blood flows can give access to this local quantities and may therefore help to design new medical devices with less negative impacts. In the case of aneurysms, numerical simulations may help to predict possible zones of rupture and could therefore give a guide for treatment planning.

In clinical routine, many indices are used for diagnosis. For example, the size of a stenosis is estimated by a few measures of flow rate around the stenosis and by application of simple fluid mechanics rules. In some situations, for example in the case a sub-valvular stenosis, it is known that such indices often give false estimations. Numerical simulations may give indications to define new indices, simple enough to be used in clinical exams, but more precise than those currently used.

It is well-known that the arterial circulation and the heart (or more specifically the left ventricle) are strongly coupled. Modifications of arterial walls or blood flows may indeed affect the mechanical properties of the left ventricle. Numerical simulations of the arterial tree coupled to the heart model could shed light on this complex relationship.

One of the goals of the REO team is to provide various models and simulation tools of the cardiovascular system. The scaling of these models will be adapted to the application in mind: low resolution for modeling the global circulation, high resolution for modeling a small portion of vessel.

Breathing, or “external” respiration (“internal” respiration corresponds to cellular respiration) involves gas transport though the respiratory tract with its visible ends, nose and mouth. Air streams then from the pharynx down to the trachea. Food and drink entry into the trachea is usually prevented by the larynx structure (epiglottis). The trachea extends from the neck into the thorax, where it divides into right and left main bronchi, which enter the corresponding lungs (the left being smaller to accommodate the heart). Inhaled air is then convected in the bronchus tree which ends in alveoli, where gaseous exchange occurs. Surfactant reduces the surface tension on the alveolus wall, allowing them to expand. Gaseous exchange relies on simple diffusion on a large surface area over a short path between the alveolus and the blood capillary under concentration gradients between alveolar air and blood. The lungs are divided into lobes (three on the right, two on the left) supplied by lobar bronchi. Each lobe of the lung is further divided into segments (ten segments of the right lung and eight of the left). Inhaled air contains dust and debris, which must be filtered, if possible, before they reach the alveoli. The tracheobronchial tree is lined by a layer of sticky mucus, secreted by the epithelium. Particles which hit the side wall of the tract are trapped in this mucus. Cilia on the epithelial cells move the mucous continually towards the nose and mouth.

Each lung is enclosed in a space bounded below by the diaphragm and
laterally by the chest wall and the mediastinum. The air movement is
achieved by alternately increasing and decreasing the chest pressure
(and volume). When the airspace transmural pressure rises, air is
sucked in. When it decreases, airspaces collapse and air is expelled.
Each lung is surrounded by a pleural cavity, except at its hilum where
the inner pleura give birth to the outer pleura. The pleural layers
slide over each other. The tidal volume is nearly equal to 500

The lungs may fail to maintain an adequate supply of air. In premature infants surfactant is not yet active. Accidental inhalation of liquid or solid and airway infection may occur. Chronic obstructive lung diseases and lung cancers are frequent pathologies and among the three first death causes in France.

One of the goals of REO team in the ventilation field is to visualize the airways (virtual endoscopy) and simulate flow in image-based 3D models of the upper airways (nose, pharynx, larynx) and the first generations of the tracheobronchial tree (trachea is generation 0), whereas simple models of the small bronchi and alveoli are used (reduced-basis element method, fractal homogenization, multiphysics homogenization, lumped parameter models), in order to provide the flow distribution within the lung segments.

The purpose is to simulate the propagation of the action potential in the heart. A lot of works has already been devoted to this topic in the literature (see *e.g.* , , and the references therein), nevertheless there are only very few studies showing realistic electrocardiograms obtained from partial differential equations models. Our goal is to find a compromise between two opposite requirements: on the one hand, we want to use predictive models, and therefore models based on physiology, on the other hand, we want to use models simple enough to be parametrized (in view of patient-specific simulations). One of the goal is to use our ECG simulator to address the inverse problem of electrocardiology. In collaboration with the Macs/M3disym project-team, we are interested in the electromechanical coupling in the myocardium. We are also interested in various clinical and industrial issues related to cardiac electrophysiology, in particular the simulation of experimental measurement of the field potential of cardiac stem cells in multi-electrode arrays.

FELiScE – standing for “Finite Elements for Life Sciences and Engineering” – is a finite element code which the M3DISYM and REO project-teams have decided to jointly develop in order to build up on their respective experiences concerning finite element simulations. One specific objective of this code is to provide in a unified software environment all the state-of-the-art tools needed to perform simulations of the complex respiratory and cardiovascular models considered in the two teams – namely involving fluid and solid mechanics, electrophysiology, and the various associated coupling phenomena. FELISCE is written in C++, and may be later released as an opensource library.

It was registered in July 2014 at the *Agence pour la Protection des Programmes* under the Inter Deposit Digital Number IDDN.FR.001.350015.000.S.P.2014.000.10000.

Gforge web site: https://

LiFE-V

SHELDDON (SHELls and structural Dynamics with DOmain decomposition in Nonlinear analysis) is a finite element library based on the Modulef package which contains shell elements, nonlinear procedures and PVM subroutines used in domain decomposition or coupling methods, in particular fluid-structure interaction.

Gforge web site: https://

Jimmy Mullaert was awarded the best poster prize at the conference Canum 2014.

Jessica Oakes was awarded a University of California Presidential Postdoctoral Fellowship.

Jessica Oakes won a young investigator award at the “4th International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease”.

We have performed an a priori error analysis for the generalized Robin-Neumann explicit
coupling schemes introduced in . The analysis confirms the

We consider the extension of the Nitsche-XFEM method to fluid-structure interaction problems involving a thin-walled elastic structure (Lagrangian formalism) immersed in an incompressible fluid (Eulerian formalism). The fluid domain is discretized with an unstructured mesh not fitted to the solid mid- surface mesh. Weak and strong discontinuities across the interface are allowed for the velocity and pressure, respectively. The kinematic/kinetic fluid-solid coupling is enforced consistently using a variant of Nitsche’s method involving cut elements. Robustness with respect to arbitrary interface/element intersections is guaranteed through a ghost penalty stabilization. Different coupling schemes, either fully implicit or loosely coupled, are proposed. Several numerical examples, involving static and moving interfaces, illustrate the performance of the methods. A paper in collaboration with F. Alauzet (project-team Gamma3) is under preparation. Results presented by B. Fabrèges at the 11th World Congress on Computational Mechanics (WCCM XI), July 20-25, 2014, Barcelona (Spain).

In we investigate the stability of numerical schemes that are classically used in the simulation of airflows and blood flows. The geometrical complexity of the networks in which air/blood flows leads to a classical decomposition of two areas: a truncated 3D geometry corresponding to the largest contribution of the domain, and a 0D part connected to the 3D part, modelling air/blood flows in smaller airways/vessels. The resulting Navier-Stokes system in the 3D truncated part may involve non-local boundary conditions, deriving from a mechanical model. For various 3D/0D coupled models, different discretization processes are presented and analyzed in terms of numerical stability, highlighting strong differences according to the regimes that are considered. In particular, two main stability issues are investigated: first the coupling between the 3D and the 0D part for which implicit or explicit strategies are studied and, second, the question of estimating the amount of kinetic energy entering the 3D domain because of the artificial boundaries. The second issue has been also the subject of a review .

In , the aim of the study was to determine susceptibility differences between healthy and emphysematous rats exposed to airborne particles. To do this, we performed animal exposure experimenters and measured particle deposition concentrations with Magnetic Resonance Imaging. We showed that overall deposition was significantly higher in the elastase-treated rats compared to the healthy ones, suggesting enhanced susceptibility to airborne particles in diseased lungs. Current work aims at integrating such experimental data into modeling and compare numerical simulations with experiments. To extend particle modeling to expiration, a 1D particle transport model is under development .

While it is known that the retention of fine particles is less in microgravity (uG) compared to normal gravity (1G) levels, it was unknown the spatial relationship of deposited particles. In , rats were exposed to 1 micron diameter particles on the NASA uG airplane and compared to rats exposed in 1G. We found that the ratio of deposited particles in the central airways compared to the peripheral ones, was significantly less in the uG than in 1G, indicating enhanced deposition in the periphery. This data suggests that toxicology effects of exposure to Moon dust may not be insignificant.

in we deal with the following data assimilation problem: construct an analytical approximation of a numerical constitutive law in three-dimensional nonlinear elasticity. More precisely we are concerned with a micro-macro model for rubber as the one proposed in . Macroscopic quantities of interest such as the Piola-Kirchhoff stress tensor can be approximated for any value of the strain gradient by numerically solving a nonlinear PDE. This procedure is however computationally demanding. Hence, although conceptually satisfactory, this physically-based model is of no direct practical use. We aim to circumvent this difficulty by proposing a numerical strategy to reconstruct from in silico experiments an accurate analytical proxy for the micro-macro constitutive law.

CIFRE convention and contract with Air Liquide Santé International in the context of the ANRT on “Multiscale lung ventilation modeling in health and disease”, for the PhD thesis of Nicolas Pozin (March 2014 - February 2017).

Period: 2012-2016

The aim of this project, coordinated by Miguel Ángel Fernández Varela, is to study mathematically and numerically new numerical methods for incompressible fluid-sructure interaction.

Period: 2013-2013.

This project, coordinated by Jean-Frédéric Gerbeau, is carried out in the framework of a joint laboratory (“LabCom” call of ANR) with the software company NOTOCORD. The focus is the mathematical modeling of a device measuring the electrical activity of cardiomyocytes. The overall objective of CardioXcomp is to enrich NOTOCORD's software with modelling and simulation solutions and provide to pharmacology research a completely new set incorporating state of the art signal processing and numerical simulation.

Period: 2013-2017.

This ANR-TecSan, co-managed by Eric Vibert (Paul Brousse Hospital) and Irene Vignon-Clementel, aims at developing an Intraoperative Fluorescent Liver Optimization Workflow to better understand the relationship between architecture, perfusion and function in hepatectomy.

Other partners: DHU Hepatinov - Hôpital Paul Brousse, Inria Mamba, Fluoptics, IfADo, MID.

Céline Grandmont is a member of the ANR TecSan Oxhelease

Marina Vidrascu is a member of the ANR ARAMIS

Period: 2014-2016

The aim of this project, coordinated by Miguel Ángel Fernández Varela, is to implement in the FELiScE library several algorithms included in the shelddon library, in particular shell elements and domain decomposition methods.

Type: FP7-PEOPLE

Instrument: Marie Curie Initial Training Network

Duration: April 2013 - March 2017

Coordinator: Andrew Hunter, University of Lincoln (UK)

Partner: See the http://revammad.blogs.lincoln.ac.uk/partners/ web site

Inria contact: J-F Gerbeau

Abstract: http://revammad.blogs.lincoln.ac.uk REVAMMAD is a European Union project aimed at combatting some of the EU’s most prevalent chronic medical conditions using retinal imaging. The project aims to train a new generation of interdisciplinary scientists for the academic, clinical and industrial sectors, and to trigger a new wave of biomedical interventions. The role of REO team within this consortium is to propose a mathematical model and a simulation tool for the retina hemodynamics.

Period: 2014-2015

Jessica Oakes was awarded an Inria@SiliconValley Grant for a post-doc at UC Berkeley to work on aerosol deposition in the lung.

Period: 2010-2015

This network, funded by the Leducq fondation, is working on the multi-scale modeling of single ventricle hearts for clinical decision support.

Other partners: see http://

Period: 2012-2015

“Systems Biology of Lung Cancer: Dynamic Properties of Early Spread and Therapeutic Options”. In collaboration with Dirk Drasdo (EPI Mamba).

Other partners: see http://

Stephanie Lindsey, PhD student at Cornell University (USA), Aug 2013 - February 2014 & 2 weeks in May 2014

Weiguang Yang, Engineering research associate, Departments of Pediatrics and Cardiology, Stanford University (USA), May 20th-June 18th 2014

Andrew Blaber, Carole Leguy, Joke Keijsers, Kouhyar Tavakolian, Simon Fraser University (Vancouver, Canada), May 26 - May 30, 2014

Matteo Aletti

Co-organizer of the monthly Junior Seminar of Inria Paris-Rocquencourt

Laurent Boudin

Co-organizer of the M2S2 workshop (Mathematical Models for Social Sciences), with J.-P. Nadal

Miguel Ángel Fernández Varela

Organizer of the CEA-EDF-Inria summer school on Numerical methods for interface problems in fluid and solids with discontinuities, Cadarache, France (with P. Massin and J. Segré), 2014

Organizer of the International workshop on numerical methods and applications in fluid-structure interactions, November 24-25, 2014, Grenoble, France (co-organized with G.-H. Cottet, J-F. Gerbeau and E. Maitre)

Jean-Frédéric Gerbeau

Organizer of the International workshop on numerical methods and applications in fluid-structure interactions, November 24-25, 2014, Grenoble, France (with G.-H. Cottet, M. Fernández and E. Maitre)

Jessica Oakes

Assistant Organizer for the 4th International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease

Student Forum Leader: International Society of Aerosol Medicine

Sanjay Pant

Co-organizer of the 4th International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease, May 21rst-22nd, Rocquencourt, France

Elisa Schenone

Co-organizer of the monthly Junior Seminar of Inria Paris-Rocquencourt

I. Vignon-Clementel

Organizer of the monthly seminar at Inria Paris-Rocquencourt on “modeling and scientific computing”

Organizer of the 4th International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease, May 21rst-22nd, Rocquencourt, France. This event was coorganized with the School of Medicine, Stanford University & REO. It was a great success! Over 70 participants came from all over the world, from the USA and France, but also from as far as Japan, Turkey or Australia. Participants particularly liked the mixture of mathematics/engineering and clinical research presented in an understandable way for both communities. This fostered lively discussions after talks and at the poster session. Three young investigators received awards from the *Fondation Sciences Mathématiques de Paris*; one of them is Stephanie Lindsey, a visiting PhD student at REO from Cornell University. http://

Organizer of the 5th general meeting of the Transatlantic Network of Excellence for Cardiovascular Research MOCHA, May 22nd-24th, Rocquencourt, France.

Jean-Frédéric Gerbeau

Editor-in-Chief of Mathematical Modelling and Numerical Analysis (M2AN).

Member of the editorial board of International Journal for Numerical Methods in Biomedical Engineering (IJNMBE).

Member of the editorial board of Communications in Applied and Industrial Mathematics.

I. Vignon-Clementel

Review Editor of Frontiers in Pediatric Cardiology.

Chloé Audebert

Minisymposium talk, 11th World Congress on Computational Mechanics (WCCM XI), July 20-25, 2014, Barcelona, Spain.

PhD students seminar, Université Paris-Decartes, February 20th, 2014, Paris, France

Poster session, 4th International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease, Inria Paris-Rocquencourt, May 21-22, 2014, Paris, France

Laurent Boudin

Invited speaker at Workshop "PDE models in social sciences", closure of Peter Markowich's chair at FSMP, Paris, France, January 2014.

Seminar, Numerical analysis and PDEs, LMPP, Univ. Lille 1, France, March 2014.

Seminar, Applied Mathematics, IMB, Univ. Bordeaux, France, March 2014.

Seminar, Mathematics and applications, Irmar, ENS Rennes, France, April 2014.

Invited speaker at Conference "Problems on kinetic theory and PDEs", Univ. Novi Sad, Serbia, September 2014.

Invited speaker at Workshop "Kinetic models for complex gases", Univ. Bordeaux, France, October 2014.

Muriel Boulakia

Contributed talk, Hybrid Inverse Problems, Paris, February 2014

Contributed talk, LJLL-Shangaï Meeting, Paris, July 2014

Contributed talk, GDR Metice workshop, Paris, November 2014

Miguel Ángel Fernández Varela

Invited plenary lecture, 12th Franco-Romanian conference on applied mathematics, Lyon (France) August 2014.

Minisymposium talk, 11th World Congress on Computational Mechanics (WCCM XI), July 20-25, 2014, Barcelona, Spain.

Seminar, University of Caen, October, 2014, France

Benoit Fabrèges

Minisymposium talk, 11th World Congress on Computational Mechanics (WCCM XI), July 20-25, 2014, Barcelona, Spain.

Contributed talk, International workshop on numerical methods and applications in fluid-structure interactions, November 24-25, Grenoble, France, 2014.

Justine Fouchet-Incaux

Contributed talk, CANUM, Carry-le-Rouet, France, April 2014.

Poster, IXème congrès de Physiologie, de Pharmacologie et de Thérapeutique, Poitiers, April 2014.

Jean-Frédéric Gerbeau

Invited plenary lecture, ESCO 2014, Pilsen (Czech Republic), June 2014

Invited plenary lecture, CARI 2014, Saint-Louis (Senegal), October 2014

Invited lecture, International Symposium Modeling and Simulation of the Cardiovascular System, Heidelberg (Germany), February 2014

Invited seminar, Collège de France, June 2014

Invited lecture, Workshop GDR Mecabio, Paris, 2014

Invited lecture, Workshop on Model Order Reduction and Data, Paris, 2014

Minisymposium talk, 7th World Congress of Biomechanics (WCB ), July 6-11, 2014, Boston, USA.

Céline Grandmont

Seminar, Nancy Univ., april 2014.

Invited speaker, PhD student day, sept. 2014.

Mikel Landajuela

Seminar, UCL/Inria Workshop on embedded interfaces, London, UK, February 25-26, 2014

Poster, International workshop on numerical methods and applications in fluid-structure interactions, Grenoble, France, November 24–25, 2014;

Damiano Lombardi

Seminar scientific computing , IMB Bordeaux, september 25

GDR Metice, Paris, 19-11-2014,

International Workshop on Fluid Structure Interaction, 24 novembre 2014, Grenoble

Jessica Oakes

Invited Seminar Talk at Technion - Israel Institute of Technology, Haifa Israel July 2014.

Seminar Talk at University of California Berkeley, Berkeley California USA, September 2014

Seminar Talk at Inria@SiliconValley Workshop, Paris France July 2014.

Poster and Podium Talk at the International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease. May 2014, Paris France.

Podium Talk at Second Aerosol Dosimetry Conference, October 2014. Irvine, California, USA.

Podium Talk at American Physics Society, Division of Fluid Dynamics, November 2014. San Francisco, California, USA

Stephanie Lindsey

Contributed talk at "American Physical Society Division of Fluid Dynamics 67th Annual Meeting", November 23-25, 2014 San Francisco, California

Invited speaker, "4th International Conference on Engineering Frontiers in Pediatric and Congenital Heart", May 21-22, 2014 Paris, France

Invited speaker, Junior Seminar, Inria, January 22, 2014 Paris, France.

Sanjay Pant

Contributed talk, Mathematics and Biology: 2nd Young Investigators International Workshop, Paris, France, April 3-4, 2014.

Poster, 4th International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease, Paris, France, May 21-22, 2014.

Contributed talk, 5th Annual Meeting of the Leducq Foundation Network of Excellence in Modeling of Single Ventricle Hearts Inria, Paris-Rocquencourt, France, May 22-24, 2014.

Elisa Schenone

Poster, 4th International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease, Paris, May 21-22 201

Seminar, Inria-Rocquencourt Junior Seminar, Paris, June 17th 2014

Seminar, PhD students working group of Jacques-Louis Lions Laboratory of UPMC, Paris, March 21st 2014

Marc Thiriet

Invited Speaker, CASTS-LJLL Workshop on Applied Mathematics and Mathematical Sciences. National Taiwan University, May 26 - 29, 2014

Keynote speaker, CompIMAGE'14, Sept. 3-5, Pittsburgh, USA

Invited Speaker, International Conference on Progress in Fluid Dynamics and Simulation, National Taiwan University, October 25-27, 2014

Miraucourt O, Génevaux O, Szopos M, Thiriet M, Talbot H, Salmon S, Passat N. s. 2014 IEEE International Symposium on Biomedical Imaging, Beijing, China, April 29 - May 2, 2014

M Thiriet, M Solovchuk, TWH Sheu, HIFU , CompIMAGE'14, Sept. 3-5, Pittsburgh, USA

Solovchuk M, Sheu TWH, Thiriet M, 1st Global Conference on Biomedical
Engineering (GCBME 2014) and 9th Asian Pacific Conference on Medical and
Biological Engineering (APCMBE 2014), Oct. 9-12, 2014, NCKU, Tainan
**Young Investigator award**

Solovchuk M, Sheu TWH, Thiriet M,, International Conference on Progress in Fluid Dynamics and Simulation, National Taiwan University October 25–27, 2014

Marina Vidrascu

Modeling and scientific computing seminar at Inria Paris-Rocquencourt on January 7th, 2014.

Seminar at Univ Compiègne, October 7th, 2014.

Irène Vignon-Clementel

Invited talk, Navier-Stokes workshop “une equation lumineuse” , Ecole Polytechnique, March 12th, Palaiseau, France.

Invited talk, Institute of Child Health, University College London, April 3rd, London, UK.

Invited talk, Notocord workshop, Inria Paris-Rocquencourt, June 6th, 2014, France.

Talk, Inria-Dassault System meeting, Oct. 29th, 2014, Paris, France .

DUT :

Justine Fouchet-Incaux 1ère année: Mathématiques S1, 28h, IUT d'Orsay, département Mesures Physiques, Université Paris-Sud,

Justine Fouchet-Incaux 2ème année: Mathématiques S4, 33h, IUT d'Orsay, département Mesures Physiques, Université Paris-Sud

Licence :

Chloé Audebert

"Calculus" (72h), L1 - undergraduate, Université Paris 6 UPMC, France (1rst semester 2014-2015).

Numerical ressources for Small Private Online Classes (SPOC), L1 - undergraduate, Université Paris 6 UPMC, France.

Laurent Boudin

Multivariable calculus and multiple integrals (114 h), L2, UPMC.

Shared studies supervision in mathematics licence for approximately 500 students (30h), L2-L3, UPMC.

Muriel Boulakia

Scilab (35h), L2, UPMC

Hilbertian analysis (45h), L3, Polytech'Paris,

Miguel Ángel Fernández Varela

Scientific computing, 30h, L3, École des Ponts ParisTech,

Céline Grandmont

Numerical Analysis, 36 h, L3, UPMC

EDO, 24 h, L3, UPMC

Damiano Lombardi

Linear Algebra TD, 32h, L1 Physique-Chimie, UP-SUD

Irène Vignon-Clementel

Mathematics for biology, 64h ETD, L1 - undergraduate, Univ. de Versailles Saint Quentin

Master :

Laurent Boudin

Basics for numerical methods (72h), M1, UPMC.

Studies supervision in mathematics master for 15 students (20h), M1, UPMC.

Muriel Boulakia

Preparatory course for teaching admission examination Agrégation (60h), M2, UPMC,

Jean-Frédéric Gerbeau

Numerical methods in hemodynamics (20h), M2, UPMC / Univ Paris-Sud / Ecole Polytechnique.

Miguel Ángel Fernández Varela

Numerical methods in bio-fluids, 6h, M2, University of Vigo, Spain.

Damiano Lombardi

Numerical Methods, 48h, Paris Polytech, M1 Robotique

Engineering schools:

Irène Vignon-Clementel. Numerical simulations of blood flow, 1h30, as part of the undergraduate "continuum mechanics" class at AgroParisTech, France

PhD: Grégory Arbia, *Multi-scale Modeling of Single Ventricle Hearts for Clinical Decision Support*, Univ Paris 6 UPMC, defended December 16, 2014. Supervisors: J-F. Gerbeau & I. Vignon-Clementel, .

PhD: Jimmy Mullaert, *Fluid-structure
interaction*, Univ Paris 6 UPMC, defended on December 17 . Supervisors: M.A. Fernández Varela& Y. Maday, .

PhD: Elisa Schenone, *Inverse problems in
electrocardiology*, Univ Paris 6 UPMC, defended on November 28. Supervisors: J-F. Gerbeau & M. Boulakia, .

PhD: Saverio Smaldone, *Numerical methods for
cardiac hemodynamics*, Univ Paris 6 UPMC, defended on October 13,
Supervisors: J-F. Gerbeau & M.A. Fernández Varela, .

PhD in progress: Chloé Audebert, *Modeling of liver hemodynamics*, since October 2013. Supervisors: J-F. Gerbeau & I. Vignon-Clementel.

PhD in progress: Justine Fouchet-Incaux, *Mathematical and numerical modeling of the human breathing*, since October 2011. Supervisors: C. Grandmont & B. Maury.

PhD in progress: Mikel Landajuela, *Coupling schemes and
unfitted mesh methods for fluid-structure interaction*, since October
2012, Supervisor: M.A. Fernández Varela.

PhD in progress: Matteo Aletti, *Multiscale retinal vascular modeling* , since January 2014 Supervisors: J-F. Gerbeau & Damiano Lombardi.

PhD in progress: Eliott Tixier, *Stem cells electrophysiology*, since September 2014
2014. Supervisors: J-F. Gerbeau & Damiano Lombardi.

PhD in progress: Nicolas Pozin *Multiscale lung
ventilation modeling in health and disease*, since March 2014. Supervisors: C. Grandmont & I. Vignon-Clementel.

PhD in progress: Stéphane Liwarek, *Air flow in the nasal cavity*, October 2010-September 2014. Supervisors: M.A. Fernández Varela & J-F. Gerbeau.

Laurent Boudin

Member of the PhD committees of Galina Vinogradova (SciencesPo, december 2014)

Muriel Boulakia

Hiring committee: UPMC and Univ. Paris-Diderot

Jean-Frédéric Gerbeau

PhD committees: Guilhem Lepoultier, Univ. Orsay (referee), Liesbeth Taelman, Univ. Gand, Belgique (referee), Adela Puscas, Univ. Paris-Est (referee), Christophe Chnafa, Univ. Montpellier 2 (referee), Agnès Leroy, Univ. Paris-Est. (member)

Hiring committee: Univ Orsay, CR2 Inria Paris-Rocquencourt, CR1 Inria.

Céline Grandmont

Hiring committee: Lyon Univ. (Assitant Professor position).

Head habilitation (HDR) committee: B. Mauroy, Nice univ.

Marina Vidrascu

Member of the Hiring committee Perpignan (professor)

Member of the PhD committee of Claire Dupont and Jimmy Mullaert

Irène Vignon-Clementel

Member of the PhD committee of Xiaofei Wang, UPMC, Oct. 17th

PhD referee of Alessia Baretta, LaBS, Politecnico di Milano, Italy, Oct 21rst.

Member of the PhD committee of Grégory Arbia, UPMC, Dec 16th.

Laurent Boudin

Member of the Board of Mathematics Licence (EFU de Licence de mathématiques), UPMC.

Member of the think-tank for third-year programs in Mathematics at UPMC.

Member of the IREM (Institutes for Research on Mathematics Teaching) Scientific Committee.

Muriel Boulakia

Supervisor of the teaching of mathematics at the engineer school Polytech Paris-UPMC

Jean-Frédéric Gerbeau

Service activity at Inria: Délégué Scientifique / Chairman of the project-teams' committee of Inria Paris-Rocquencourt research center; Member of the Inria Evaluation Committee; Member of the Inria International Chairs committee.

Service activity in other French institutions: member of the research committee of Sorbonne Universités; member of the scientific committee of the Faculty of Science, University Versailles Saint-Quentin; member of the scientific committee of Labex NUMEV, Montpellier.

Service activity abroad: member of the Reference Committee of the PhD program Mathematical Models and Methods in Engineering (Politecnico di Milano, Italy);

Céline Grandmont

Member of the CNU 26 (2011–2015). Member of the CNU extended board.

Marc Thiriet

President of thematic comittee CT3 (Biomedical Simulation and Applications to Health) of GENCI (Grand Equipement National de Calcul Intensif – National Large Equipement for Intensive Computation).

Member of Evaluation Groups of the Canadian Granting Agency NSERC 1501 (Genes, Cells and Molecules), 1502 (Biological Systems and Functions), 1504 (Chemistry), 1507 (Computer Science), 1508 (Mathematics and Statistics), 1511 (Materials and Chemical Eng.), and mainly 1512 (Mechanical Eng., both Solids and Fluids sections).

Member of Scientific Council of DiscInNet

Marina Vidrascu

Member of the post-docs selection committee, Inria Paris-Rocquencourt

Irène Vignon-Clementel

Member of the PhD grant committee, Inria Paris-Rocquencourt

Mediator between PhD students and their supervisors for Inria Paris-Rocquencourt

Matteo Aletti

presentation at "Incontro Neo-Laureati" (Conférance jeunes diplômes) at Politecnico di Milano

presentation about REVAMMAD project at ArtVerona

Céline Grandmont

Popularization paper "Inspiration mathématique: la modélisation du poumon", in Mathématique l'explosion continue, edited by SFdS, SMAI, SMF.

Conference «Nuit des Sciences, ébulition», ENS Paris, june 2014

Conference «Mathematic Park a Bobigny», 300 students (high school level), oct. 2014

Conference «Filles et Maths: une equation lumineuse», 60 students, (high school level), oct. 2014.

Irene Vignon-Clementel

Conference in High School Blanche de Castille, March 25th, Le Chesnay