REO is a joint project-team of the Inria Research Center of Paris and the Jacques-Louis Lions Laboratory (LJLL) of the Pierre and Marie Curie University (UPMC Paris 6) and CNRS (UMR7598). Its main objectives are:

the modeling of blood flow in large vessels, air flow in the respiratory tract, and the cardiac electrophysiology;

the design and the analysis of efficient and robust numerical methods for these problems;

the development of numerical software to assist medical decisions and to contribute to the design of medical devices.

REO put a strong effort in working with real data, coming either from clinicians or industrial partners. The development of methods for the interaction of data and simulation is therefore an important aspect of the activity of the team.

In large vessels and in large bronchi, blood and air flows are generally supposed to be governed by the incompressible Navier-Stokes equations. Indeed in large arteries, blood can be supposed to be Newtonian, and at rest air can be modeled as an incompressible fluid. The cornerstone of the simulations is therefore a Navier-Stokes solver. But other physical features have also to be taken into account in simulations of biological flows, in particular fluid-structure interaction in large vessels and transport of sprays, particles or chemical species.

Fluid-structure coupling occurs both in the respiratory and in the circulatory systems. We focus mainly on blood flows since our work is more advanced in this field. But the methods developed for blood flows could be also applied to the respiratory system.

Here “fluid-structure interaction” means a coupling between the 3D Navier-Stokes equations and a 3D (possibly thin) structure in large displacements.

The numerical simulations of the interaction between the artery wall and the blood flows raise many issues: (1) the displacement of the wall cannot be supposed to be infinitesimal, geometrical nonlinearities are therefore present in the structure and the fluid problem have to be solved on a moving domain (2) the densities of the artery walls and the blood being close, the coupling is strong and has to be tackled very carefully to avoid numerical instabilities, (3) “naive” boundary conditions on the artificial boundaries induce spurious reflection phenomena.

Simulation of valves, either at the outflow of the cardiac chambers or in veins, is another example of difficult fluid-structure problems arising in blood flows. In addition, very large displacements and changes of topology (contact problems) have to be handled in those cases.

Due to stability reasons, it seems impossible to successfully apply in hemodynamics the explicit coupling schemes used in other fluid-structure problems, like aeroelasticity. As a result, fluid-structure interaction in biological flows raise new challenging issues in scientific computing and numerical analysis : new schemes have to be developed and analyzed.

We have proposed and analyzed over the last few years several efficient fluid-structure interaction algorithms. This topic remains very active. We are now using these algorithms to address inverse problems in blood flows to make patient specific simulations (for example, estimation of artery wall stiffness from medical imaging).

Complex two-phase fluids can be modeled in many different ways. Eulerian models describe both phases by physical quantities such as the density, velocity or energy of each phase. In the mixed fluid-kinetic models, the biphasic fluid has one dispersed phase, which is constituted by a spray of droplets, with a possibly variable size, and a continuous classical fluid.

This type of model was first introduced by Williams
in the frame of combustion. It was later used to develop the Kiva
code at the Los Alamos National Laboratory, or the
Hesione code , for example. It has a wide range of
applications, besides the nuclear setting: diesel engines, rocket
engines , therapeutic sprays, *etc.* One of the
interests of such a model is that various phenomena on the
droplets can be taken into account with an accurate precision:
collision, breakups, coagulation, vaporization, chemical reactions,
*etc.*, at the level of the droplets.

The model usually consists in coupling a kinetic equation, that describes the spray through a probability density function, and classical fluid equations (typically Navier-Stokes). The numerical solution of this system relies on the coupling of a method for the fluid equations (for instance, a finite volume method) with a method fitted to the spray (particle method, Monte Carlo).

We are mainly interested in modeling therapeutic sprays either for local or general treatments. The study of the underlying kinetic equations should lead us to a global model of the ambient fluid and the droplets, with some mathematical significance. Well-chosen numerical methods can give some tracks on the solutions behavior and help to fit the physical parameters which appear in the models.

Multiscale modeling is a necessary step for blood and respiratory flows. In this section, we focus on blood flows. Nevertheless, similar investigations are currently carried out on respiratory flows.

Problems arising in the numerical modeling of the human cardiovascular
system often require an accurate description of the flow in a specific
sensible subregion (carotid bifurcation, stented artery, *etc.*).
The description of such local phenomena is better addressed by means
of three-dimensional (3D) simulations, based on the numerical
approximation of the incompressible Navier-Stokes equations, possibly
accounting for compliant (moving) boundaries. These simulations
require the specification of boundary data on artificial boundaries
that have to be introduced to delimit the vascular district under
study. The definition of such boundary conditions is critical and, in
fact, influenced by the global systemic dynamics. Whenever the
boundary data is not available from accurate measurements, a proper
boundary condition requires a mathematical description of the action
of the reminder of the circulatory system on the local district. From
the computational point of view, it is not affordable to describe the
whole circulatory system keeping the same level of detail. Therefore,
this mathematical description relies on simpler models, leading to the
concept of *geometrical multiscale* modeling of the circulation
. The underlying idea consists in coupling
different models (3D, 1D or 0D) with a decreasing level of accuracy,
which is compensated by their decreasing level of computational
complexity.

The research on this topic aims at providing a correct methodology and a mathematical and numerical framework for the simulation of blood flow in the whole cardiovascular system by means of a geometric multiscale approach. In particular, one of the main issues will be the definition of stable coupling strategies between 3D and reduced order models.

To model the arterial tree, a standard way consists of imposing a
pressure or a flow rate at the inlet of the aorta, *i.e.* at the
network entry. This strategy does not allow to describe important
features as the overload in the heart caused by backward traveling
waves. Indeed imposing a boundary condition at the beginning of the
aorta artificially disturbs physiological pressure waves going from
the arterial tree to the heart. The only way to catch this
physiological behavior is to couple the arteries with a model of
heart, or at least a model of left ventricle.

A constitutive law for the myocardium, controlled by an electrical
command, has been developed in the CardioSense3D project

A long term goal is to achieve 3D simulations of a system including heart and arteries. One of the difficulties of this very challenging task is to model the cardiac valves. To this purpose, we investigate a mix of arbitrary Lagrangian Eulerian and fictitious domain approaches or x-fem strategies, or simplified valve models based on an immersed surface strategy.

The heart is the organ that regulates, through its periodical contraction, the distribution of oxygenated blood in human vessels in order to nourish the different parts of the body. The heart needs its own supply of blood to work. The coronary arteries are the vessels that accomplish this task. The phenomenon by which blood reaches myocardial heart tissue starting from the blood vessels is called in medicine perfusion. The analysis of heart perfusion is an interesting and challenging problem. Our aim is to perform a three-dimensional dynamical numerical simulation of perfusion in the beating heart, in order to better understand the phenomena linked to perfusion. In particular the role of the ventricle contraction on the perfusion of the heart is investigated as well as the influence of blood on the solid mechanics of the ventricle. Heart perfusion in fact implies the interaction between heart muscle and blood vessels, in a sponge-like material that contracts at every heartbeat via the myocardium fibers.

Despite recent advances on the anatomical description and measurements of the coronary tree and on the corresponding physiological, physical and numerical modeling aspects, the complete modeling and simulation of blood flows inside the large and the many small vessels feeding the heart is still out of reach. Therefore, in order to model blood perfusion in the cardiac tissue, we must limit the description of the detailed flows at a given space scale, and simplify the modeling of the smaller scale flows by aggregating these phenomena into macroscopic quantities, by some kind of “homogenization” procedure. To that purpose, the modeling of the fluid-solid coupling within the framework of porous media appears appropriate.

Poromechanics is a simplified mixture theory where a complex
fluid-structure interaction problem is replaced by a superposition of
both components, each of them representing a fraction of the complete
material at every point. It originally emerged in soils mechanics with
the work of Terzaghi , and Biot later
gave a description of the mechanical behavior of a porous medium using
an elastic formulation for the solid matrix, and Darcy's law for the
fluid flow through the matrix. Finite strain poroelastic models have
been proposed (see references in ), albeit with *ad hoc* formulations for which compatibility with thermodynamics laws and incompressibility conditions is not established.

The same way the myocardium needs to be perfused for the heart to beat, when it has reached a certain size, tumor tissue needs to be perfused by enough blood to grow. It thus triggers the creation of new blood vessels (angiogenesis) to continue to grow. The interaction of tumor and its micro-environment is an active field of research. One of the challenges is that phenomena (tumor cell proliferation and death, blood vessel adaptation, nutrient transport and diffusion, etc) occur at different scales. A multi-scale approach is thus being developed to tackle this issue. The long term objective is to predict the efficiency of drugs and optimize therapy of cancer.

We aim at developing a multiscale model of the respiratory tract. Intraprenchymal airways distal from generation 7 of the tracheabronchial tree (TBT), which cannot be visualized by common medical imaging techniques, are modeled either by a single simple model or by a model set according to their order in TBT. The single model is based on straight pipe fully developed flow (Poiseuille flow in steady regimes) with given alveolar pressure at the end of each compartment. It will provide boundary conditions at the bronchial ends of 3D TBT reconstructed from imaging data. The model set includes three serial models. The generation down to the pulmonary lobule will be modeled by reduced basis elements. The lobular airways will be represented by a fractal homogenization approach. The alveoli, which are the gas exchange loci between blood and inhaled air, inflating during inspiration and deflating during expiration, will be described by multiphysics homogenization.

Cardiovascular diseases like atherosclerosis or aneurysms are a major cause of mortality. It is generally admitted that a better knowledge of local flow patterns could improve the treatment of these pathologies (although many other biophysical phenomena obviously take place in the development of such diseases). In particular, it has been known for years that the association of low wall shear stress and high oscillatory shear index give relevant indications to localize possible zones of atherosclerosis. It is also known that medical devices (graft or stent) perturb blood flows and may create local stresses favorable with atherogenesis. Numerical simulations of blood flows can give access to this local quantities and may therefore help to design new medical devices with less negative impacts. In the case of aneurysms, numerical simulations may help to predict possible zones of rupture and could therefore give a guide for treatment planning.

In clinical routine, many indices are used for diagnosis. For example, the size of a stenosis is estimated by a few measures of flow rate around the stenosis and by application of simple fluid mechanics rules. In some situations, for example in the case a sub-valvular stenosis, it is known that such indices often give false estimations. Numerical simulations may give indications to define new indices, simple enough to be used in clinical exams, but more precise than those currently used.

It is well-known that the arterial circulation and the heart (or more specifically the left ventricle) are strongly coupled. Modifications of arterial walls or blood flows may indeed affect the mechanical properties of the left ventricle. Numerical simulations of the arterial tree coupled to the heart model could shed light on this complex relationship.

One of the goals of the REO team is to provide various models and simulation tools of the cardiovascular system. The scaling of these models will be adapted to the application in mind: low resolution for modeling the global circulation, high resolution for modeling a small portion of vessel.

Breathing, or “external” respiration (“internal” respiration corresponds to cellular respiration) involves gas transport though the respiratory tract with its visible ends, nose and mouth. Air streams then from the pharynx down to the trachea. Food and drink entry into the trachea is usually prevented by the larynx structure (epiglottis). The trachea extends from the neck into the thorax, where it divides into right and left main bronchi, which enter the corresponding lungs (the left being smaller to accommodate the heart). Inhaled air is then convected in the bronchus tree which ends in alveoli, where gaseous exchange occurs. Surfactant reduces the surface tension on the alveolus wall, allowing them to expand. Gaseous exchange relies on simple diffusion on a large surface area over a short path between the alveolus and the blood capillary under concentration gradients between alveolar air and blood. The lungs are divided into lobes (three on the right, two on the left) supplied by lobar bronchi. Each lobe of the lung is further divided into segments (ten segments of the right lung and eight of the left). Inhaled air contains dust and debris, which must be filtered, if possible, before they reach the alveoli. The tracheobronchial tree is lined by a layer of sticky mucus, secreted by the epithelium. Particles which hit the side wall of the tract are trapped in this mucus. Cilia on the epithelial cells move the mucous continually towards the nose and mouth.

Each lung is enclosed in a space bounded below by the diaphragm and
laterally by the chest wall and the mediastinum. The air movement is
achieved by alternately increasing and decreasing the chest pressure
(and volume). When the airspace transmural pressure rises, air is
sucked in. When it decreases, airspaces collapse and air is expelled.
Each lung is surrounded by a pleural cavity, except at its hilum where
the inner pleura give birth to the outer pleura. The pleural layers
slide over each other. The tidal volume is nearly equal to 500

The lungs may fail to maintain an adequate supply of air. In premature infants surfactant is not yet active. Accidental inhalation of liquid or solid and airway infection may occur. Chronic obstructive lung diseases and lung cancers are frequent pathologies and among the three first death causes in France.

One of the goals of REO team in the ventilation field is to visualize the airways (virtual endoscopy) and simulate flow in image-based 3D models of the upper airways (nose, pharynx, larynx) and the first generations of the tracheobronchial tree (trachea is generation 0), whereas simple models of the small bronchi and alveoli are used (reduced-basis element method, fractal homogenization, multiphysics homogenization, lumped parameter models), in order to provide the flow distribution within the lung segments.

The purpose is to simulate the propagation of the action potential in the heart. A lot of works has already been devoted to this topic in the literature (see *e.g.* , , and the references therein), nevertheless there are only very few studies showing realistic electrocardiograms obtained from partial differential equations models. Our goal is to find a compromise between two opposite requirements: on the one hand, we want to use predictive models, and therefore models based on physiology, on the other hand, we want to use models simple enough to be parametrized (in view of patient-specific simulations). One of the goal is to use our ECG simulator to address the inverse problem of electrocardiology. In collaboration with the Macs/M3disim project-team, we are interested in the electromechanical coupling in the myocardium. We are also interested in various clinical and industrial issues related to cardiac electrophysiology, in particular the simulation of experimental measurement of the field potential of cardiac stem cells in multi-electrode arrays.

Irène Vignon-Clementel: Article selected for journal cover in Cardiovascular Engineering and Technology.

Jessica Oakes was awarded an American Lung Association Senior Research Training Grant for salary support for 1-2 years.

Finite Elements for Life SCiences and Engineering problems

Keywords: Finite element modelling - Cardiac Electrophysiology - Cardiovascular and respiratory systems

Functional Description

FELiScE is a finite element code which the M3DISIM and REO project-teams have decided to jointly develop in order to build up on their respective experiences concerning finite element simulations. One specific objective of this code is to provide in a unified software environment all the state-of-the-art tools needed to perform simulations of the complex respiratory and cardiovascular models considered in the two teams – namely involving fluid and solid mechanics, electrophysiology, and the various associated coupling phenomena. FELISCE is written in C++, and may be later released as an opensource library. FELiScE was registered in July 2014 at the Agence pour la Protection des Programmes under the Inter Deposit Digital Number IDDN.FR.001.350015.000.S.P.2014.000.10000.

Participants: Dominique Chapelle, Miguel Angel Fernandez Varela, Jean-Frédéric Gerbeau, Philippe Moireau, Marina Vidrascu, Sébastien Gilles, Benoit Fabreges, Axel Fourmont, Mikel Landajuela Larma, Damiano Lombardi, Matteo Aletti, Irène Vignon-Clementel and Faisal Amlani

Contact: Jean-Frédéric Gerbeau

Keyword: Finite element modelling

Functional Description

LiFE-V is a finite element library providing implementations of state of the art mathematical and numerical methods. It serves both as a research and production library. LiFE-V is the joint collaboration between three institutions: Ecole Polytechnique Fédérale de Lausanne (CMCS) in Switzerland, Politecnico di Milano (MOX) in Italy and Inria (REO) in France. It is a free software under LGPL license.

Participants: Jean-Frédéric Gerbeau and Miguel Angel Fernandez Varela

Partners: EPFL - Ecole Polytechnique Fédérale de Lausanne - MOX Politecnico di Milano

Contact: Miguel Angel Fernández Varela

SHELls and structural Dynamics with DOmain decomposition in Nonlinear analysis

Functional Description

SHELDDON is a finite element library based on the Modulef package which contains shell elements, nonlinear procedures and PVM subroutines used in domain decomposition or coupling methods, in particular fluid-structure interaction.

Participants: Dominique Chapelle, Patrick Le Tallec and Marina Vidrascu

Contact: Marina Vidrascu

In and we study the effect of wall bending resistance on the motion of an initially spherical capsule freely suspended in shear flow or in a a planar hyperbolic flow. We consider a capsule with a given thickness made of a three–dimensional homogeneous elastic material. A numerical method is used to model the coupling of a boundary integral method for the fluids with a shell finite element method for the capsule envelope. For a given wall material, the capsule deformability strongly decreases when the wall bending resistance increases. In addition, if one expresses the same results as a function of the two–dimensional mechanical properties of the mid–surface, which is how the capsule wall is modeled in the thin–shell model, the capsule deformed shape is identical to the one predicted for a capsule devoid of bending resistance. The bending rigidity is found to have a negligible influence on the overall deformation of an initially spherical capsule, which therefore depends only on the elastic stretching of the mid–surface. Still, the bending resistance of the wall must be accounted for to model the buckling phenomenon, which is observed locally at low flow strength and persist at steady state. We show that the wrinkle wavelength only depends on the bending number, which compares the relative importance of bending and shearing phenomena, and provide the correlation law. Such results can then be used to infer values of the bending modulus and wall thickness from experiments on spherical capsules in simple shear flow.

In we study the effects of inserted needle on the subcutaneous interstitial flow. A goal is to describe the physical stress affecting cells during acupuncture treatment. The model consists of the convective Brinkman equations to describe the flow through a fibrous medium. Numerical studies in FreeFem++ are performed to illustrate the acute physical stress developed by the implantation of a needle that triggers the physiological reactions of acupuncture. We emphasize the importance of numerical experiments for advancing in modeling in acupuncture. In we show that the acupoint must contain a highly concentrated population of mastocytes (e.g., very-high–amplitude, small-width Gaussian distribution) to get an initial proper response. Permanent signaling is provided by chemotaxis and continuous recruitment of mastocytes. Therefore, the density and distribution of mastocytes are crucial factors for efficient acupuncture as well as availability of circulating and neighboring pools of mastocytes.

In silico models of flow and transport in the lung are increasingly being used to predict regional deposition in healthy and diseased lungs. However, very few models have been validated with in vivo human or animal experimental data. In , we create a physiologically-based simulation of airflow and particle transport in healthy and emphysematous rat lungs. Excellent agreement between the numerical predictions and experimental data is found for the healthy lungs. However, the numerical predictions are unable to predict the experimental findings of enhanced deposition in the normal regions of the emphysematous lungs and thus more sophisticated models of transport in the deep regions of the lung are needed. This is what is being explored in , where interactions of flow and transport between 3D upper-parts and 1D downstream respiratory trees are captured for inspiration and expiration for the first time.

While several groups have investigated detailed flow and particle transport in the acinar regions of the healthy lung, little is currently known about diseased acini. In we perform numerical simulations of flow and transport in healthy and emphysematous acini. As the alveolar septa is deteriorated in emphysema there is less surface area available for particles to deposit on. Therefore, fewer particles deposit in the diseased models. In addition, we find that particle deposition is more heterogeneously distributed in emphysema, a phenomenon that was also found in the in vivo animal experiments.

The articles , presented in the section about biological flows, and , presented in the section about electrophysiology, also present methods concerning the interaction data - simulation.

CIFRE convention and contract with Air Liquide Santé International in the context of the ANRT on “Multiscale lung ventilation modeling in health and disease”, for the PhD thesis of Nicolas Pozin (March 2014 - February 2017).

Period: 2012-2016

The aim of this project, coordinated by Miguel Ángel Fernández Varela, is to study mathematically and numerically new numerical methods for incompressible fluid-sructure interaction.

Period: 2013-2016.

This project, coordinated by Jean-Frédéric Gerbeau, is carried out in the framework of a joint laboratory (“LabCom” call of ANR) with the software company NOTOCORD. The focus is the mathematical modeling of a device measuring the electrical activity of cardiomyocytes. The overall objective of CardioXcomp is to enrich NOTOCORD's software with modelling and simulation solutions and provide to pharmacology research a completely new set incorporating state of the art signal processing and numerical simulation.

Period: 2013-2017.

This ANR-TecSan, co-managed by Eric Vibert (Paul Brousse Hospital) and Irène Vignon-Clementel, aims at developing an Intraoperative Fluorescent Liver Optimization Workflow to better understand the relationship between architecture, perfusion and function in hepatectomy.

Other partners: DHU Hepatinov - Hôpital Paul Brousse, Inria Mamba, Fluoptics, IfADo, MID.

Period: 2015-2019.

The objective of this project, coordinated by Takéo Takahashi (Inria Nancy Grand-Est), is the mathematical analysis of systems involving structures immersed in a fluid. This includes the asymptotic analysis, the study of the controllability and stabilization of fluid-structure interaction systems, the understanding of the motion of self-propelled structures and the analysis and development of numerical methods to simulate fluid-structure systems.

Laurent Boudin is a member of the ANR Blanc project Kibord on kinetic models in biology and related domains

Laurent Boudin is a member of the ANR TecSan Oxhelease

Céline Grandmont is a member of the ANR TecSan Oxhelease

Marina Vidrascu is a member of the ANR ARAMIS

Period: 2014-2016

The aim of this project, coordinated by Miguel Ángel Fernández Varela, is to implement in the FELiScE library several algorithms included in the shelddon and Modulef library, in particular shell elements and domain decomposition methods.

Title: "Retinal Vascular Modeling, Measurement and Diagnosis"

Programm: FP7

Duration: April 2013 - March 2017

Coordinator: University of Lincoln

Partners: See the web site http://

Inria contact: J.-F. Gerbeau

REVAMMAD is a European Union project aimed at combatting some of the EU’s most prevalent chronic medical conditions using retinal imaging. The project aims to train a new generation of interdisciplinary scientists for the academic, clinical and industrial sectors, and to trigger a new wave of biomedical interventions. The role of REO team within this consortium is to propose a mathematical model and a simulation tool for the retina hemodynamics. See http://

Period: 2014-2015

Jessica Oakes was awarded an Inria@SiliconValley Grant for a post-doc at UC Berkeley to work on aerosol deposition in the lung.

Period: 2010-2015

This network, funded by the Leducq fondation, is working on the multi-scale modeling of single ventricle hearts for clinical decision support.

Other partners: see http://

Period: 2012-2015

“Systems Biology of Lung Cancer: Dynamic Properties of Early Spread and Therapeutic Options”. In collaboration with Dirk Drasdo (EPI Mamba).

Other partners: see http://

Laurent Boudin

Member of the French-Italian Galileo PHC on the kinetic modelling and numerical simulation of gaseous mixtures and plasmas, supervised by F. Charles (UPMC) for France.

Member of a French-Serbian CNRS PICS on the kinetic modelling of gaseous mixtures, supervised by B. Grec (Université Paris-Descartes) for France.

Visiting PhD student: Stephanie Lindsey, Cornell University (May 4th - May 20th)

Matteo Aletti

Co-organizer of the monthly Junior Seminar of Inria Paris-Rocquencourt

Laurent Boudin

Member of the scientific committee of the “EDP Normandie 2015” conference.

Sanjay Pant

Program committee member for the Australasian Conference on Artificial Life and Computational Intelligence (ACALCI), 2016.

Jessica Oakes

ISAM Student Leader and 2015 Student Activity Conference Organizer

I. Vignon-Clementel

Organizer of a minisymposium at the 4th International Conference on Computational & Mathematical Biomedical Engineering, July 2015, Cachan, France

Organizer of the monthly seminar at Inria Paris-Rocquencourt on “modeling and scientific computing”

J-F. Gerbeau

Scientific Committee of the ENUMATH 2015 conference. Ankara, Turkey.

International Advisory Committee of the 2nd International Workshop on Latest Advances in Cardiac Modeling, 2015. Munich, Germany.

J-F. Gerbeau

Expert evaluator for Horizon2020 FET OPEN RIA Call 2015/2.

Member of the Mathematics panel of the FCT, the national funding agency of Portugal (*Fundação para a Ciência e a Tecnologia*).

M. Thiriet

European Research Council - Advanced Grant (run 2)

ANRT

Fund for Scientific Research - FNRS, Belgium

Jean-Frédéric Gerbeau

Editor-in-Chief of Mathematical Modelling and Numerical Analysis (M2AN).

Series editor of “SEMA SIMAI Springer Series”.

Member of the editorial board of International Journal for Numerical Methods in Biomedical Engineering (IJNMBE).

Member of the editorial board of Communications in Applied and Industrial Mathematics.

Member of the editorial board of Journal for Modeling in Ophthalmology.

I. Vignon-Clementel

Editor of Frontiers in Pediatric Cardiology

M. Thiriet

Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization.

Laurent Boudin

Member of the Board of Mathematics Licence (EFU de Licence de mathématiques), UPMC

Member of the think-tank for third-year programs in Mathematics at UPMC.

Member of the IREM (Institutes for Research on Mathematics Teaching) Scientific Committee.

Member of the SMAI (French Society for applied and industrial mathematics) Teaching Committee.

Muriel Boulakia

Supervisor of the teaching of mathematics at the engineer school Polytech Paris-UPMC

Miguel Ángel Fernández Varela

Co-president of the Scientific Positions Commission, Inria Paris-Rocquencourt

Jean-Frédéric Gerbeau

Service activity at Inria: Délégué Scientifique / Chairman of the project-teams' committee of Inria Paris-Rocquencourt research center; Member of the Inria Evaluation Committee; Member of the Inria International Chairs committee.

Service activity in other French institutions: member of the research committee of Sorbonne Universités; member of the scientific committee of Labex NUMEV, Montpellier.

Service activity abroad: member of the Reference Committee of the PhD program Mathematical Models and Methods in Engineering (Politecnico di Milano, Italy).

Céline Grandmont

Member of the CNU 26 (2011–2015). Member of the CNU extended board.

Member of the Evaluation Committee Inria (2015-…)

I. Vignon-Clementel

Mediator between PhD students and their supervisors for Inria Paris-Rocquencourt

Matteo Aletti

Minisymposium talk, 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE2015), June 29 - July 1, 2015, Cachan, France

Minisymposium talk, 13th U.S. National Congress on Computational Mechanics (USNCCM13), July 27 - July 30, 2015, San Diego, CA

Presentation at REVAMMAD (EU Marie Curie ITN) meeting, September 2015, Padova, Italy

Chloé Audebert

Minisymposium talk, 4th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2015, June 29th - July 1st, 2015, Cachan, France

PhD students seminar, Inria-Rocquencourt Junior Seminar, October 20th, 2015, Paris, France

Seminar, Laboratoire de mathématiques de Besançon, Université de Franche-Comté, November 12th, 2015, Besançon, France

PhD students seminar, Laboratoire de mathématiques de Versailles, Université Versailles St-Quentin, December 3rd, 2015, Paris, France

Laurent Boudin

Seminar, Analysis, LMPT, Univ. Tours, France, March 2015.

Seminar, Applied Mathematics, LMNO, Univ. Caen, France, March 2015.

Invited speaker, Workshop "From opinion dynamics to voting, conflict and terrorism", Sciences Po Paris, France, March 2015

Invited speaker, Labex SMART Summer School on "Computational Social and Behavioral Sciences", UPMC, France, September 2015

Seminar, Numerical analysis and PDEs, LMO, Univ. Paris-Sud, France, December 2015

Muriel Boulakia

November 2015 : Seminar at University College London

August 2015 : Workshop PDE, optimal design and numerics, Benasque (Spain)

April 2015 : Seminar at Université d’Orsay Paris-Sud

Miguel Ángel Fernández Varela

Invited speaker, Workshop on fluid-structure interactions: an asymptotic approach, A Coruña, Spain, October 8-9, 2015

Minisymposium talk, X-DMS 2015 eXtended Discretization MethodS conference, Ferrara, Italy, September 9-11, 2015

Invited speaker, Workshop on Control and Numerics for Fluid-Structure Interaction Problems, TFIR CAM, Bangalore, India, June 29-July 1, 2015

Invited speaker, Numerical analysis week of Besançon on XFEM, Nitsche FEM, adaptive FEM and artificial boundary contitions, Besançon, France, June 15-19, 2015

Seminar, Modeling and Scientific Computing Seminar, Inria Paris-Rocquencourt, March 3, 2015

Benoit Fabrèges

Seminar, MOX Seminar at Politenico di Milano, Milan, Italy, July 28, 2015

Jean-Frédéric Gerbeau

Invited lecture at the Edinburgh Mathematical Society, 2015

Invited lecture, 2d International Workshop on Latest Advances in Cardiac Modeling (LACM), Munich, 2015

Invited lecture, 3rd Workshop on Model Reduction (MORE), Pilsen, Czech Republic, 2015

Seminar, MOX, Politecnico di Milan, Italy, March, 2015

Seminar, ENS Rennes, Dec 16, 2015

Minisymposium talk, USNCCM, San Diego, USA, 2015

Céline Grandmont

Invited speaker, Lions-Magenes day, April 2015, Pavia, Italy

Invited Speaker, Workshop on Control and Numerics for Fluid-Structure Interaction Problems, TFIR CAM, Bangalore, India, June 29-July 1, 2015

Mikel Landajuela

Contributed talk, 13th U.S. National Congress on Computational Mechanics, San Diego, USA, July 26–30, 2015

Seminar, 2nd UCL/Inria Workshop on embedded interfaces, UPMC, Paris, France, April 8, 2015

Seminar, MOX, Milano, Italy, December 10, 2015

Damiano Lombardi

Invited talk, Optimal Transport workshop, Bordeaux, October 16 2015

Seminar, Bordeaux, *On the Backward Uncertainty Quantification problem*, March 2015

Seminar, Laboratoire Jacques Louis Lions, UPMC, December, Paris, 2015

Minisymposium talk, 1st Pan-American Congress on Computational Mechanics, Buenos Aires, Argentina, April 27-29, 2015

Jessica Oakes

Invited talk, Computational Fluid Dynamics in Medicine and Biology. Albufeira, Portugal. September 2015

Seminar, University at Buffalo, December 2015

Seminar, University of California, Los Angeles. November 2015

Seminar, University of California, Irvine. October 2015

Seminar, University of Arizona, Tucson. February 2015

Seminar, University of California, Davis. January 2015

Contributed talk 13th U.S. National Congress on Computational Mechanics. San Diego, California. July 2015

Contributed talk 4th International Conference on Computational and Mathematical Biomedical Engineering. June 2015

Poster, International Society of Aerosol Medicine. Munich, Germany. June 2015

Sanjay Pant

Seminar, King's College London, UK, October 2015

Seminar, Great Ormond Street Hospital, London, UK, October 2015

Contributed talk, 13th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, CMBBE , Montreal, Canada, September 2015

Contributed talk, 4th International Conference on Computational & Mathematical Biomedical Engineering, CMBE, Cachan, France, June–July, 2015

Nicolas Pozin

Poster, 20th International Congress on Aerosols in Medicine and Pulmonary Drug Delivery, May 30 - June 3, 2015, Munich, Germany

Marc Thiriet

Invited speaker, Second Tbilisi-Salerno Workshop on Modeling in Mathematics, Tbilisi, Mars 16-18, 2015

Keynote speaker, First Computational Mechanics Conference in Taiwan (ACMT), minisymposium MS017. Computational Biomedicine and Biomechanics, October 21–23, 2015, National Taiwan University, Taipei

Invited speaker, First Computational Mechanics Conference in Taiwan (ACMT), minisymposium MS017. Computational Biomedicine and Biomechanics, October 21–23, 2015, National Taiwan University, Taipei

Eliott Tixier

Invited speaker, Lions-Magenes Days Scientific Meeting, April 13-14, 2015, Pavia, Italy.

Minisymposium talk, 1st International Conference on Uncertainty Quantification in Computational Sciences (UNCECOMP 2015), May 25-27, 2015, Crete Island, Greece.

Minisymposium talk, 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE 2015), June 29 - July 1, 2015, Cachan, France.

Marina Vidrascu

Invited speaker, Workshop on numerical approximations of PDEs Honoring the 60th birthday of Fréderic Hecht, Málaga, Apri20-22

Invited speaker, Progrès récents en mécanique des fluides numérique. Colloque en l'honneur d'Alain Dervieux, april 10, Inria Sophia-Antipolis

Irène Vignon-Clementel

Invited talk, Workshop DHU Hepatinov, Dec. 4th, Paul Brousse Hospital, Villejuif, France

Invited talk, CEA-GAMNI workshop, Feb. 5th, Paris, France

Invited talk, Computational Fluid Dynamics (CFD) in Medicine and Biology II, Sept. 2nd, Albufeira, Portugal

Seminar, Laboratoire Jacques Louis Lions, UPMC, April 3rd, Paris, France

Seminar, Paul Brousse Hospital meeting with ESPCI, March 16th, Villejuif, France

Talk, 4th International Conference on Computational & Mathematical Biomedical Engineering, July, Cachan, France

Evaluation seminar, ANR iFLOW midterm review, Nov 3rd, Paris, France

Licence :

Chloé Audebert

Sequences and series of functions, series, generalised integrals, 20h, L2-CNED, UPMC

Laurent Boudin

Introduction to series for signal theory, 18h, L2, UPMC

Shared studies supervision in mathematics licence for approximately 500 students, 30h, L2-L3, UPMC

Mathematics licence supervision of all the “Double majeure” intensive bi-disciplinary curriculum, 4h, L2, UPMC

Muriel Boulakia

Scilab, 35h, L2, UPMC

Hilbertian analysis, 30h, L3, Polytech’Paris

Oral tests in numerical analysis, 20h, L3, UPMC

Miguel Ángel Fernández Varela

Scientific Computing, 32h, L3, ENPC

Analysis and Scientific Computing, 31h, L3, ENPC

Céline Grandmont

Professional insertion and orientation, 24h, L2, UPMC

EDO, 24h, L3, UPM

Damiano Lombardi

Numerical methods, 48h, L3, Polytech’Paris

Eliott Tixier

Matrix calculus, 36h, L1, UPMC

Linear algebra, 60h, L2, UPMC

Irène Vignon-Clementel

Mathematics for biology, 54h, L1, Université de Versailles Saint Quentin

Numerical simulations of blood flow, 1,5h, as part of the undergraduate "continuum mechanics", AgroParisTech

Master :

Laurent Boudin

Basics for numerical methods, 36h, M1, UPMC

Muriel Boulakia

Preparatory course for teaching admission examination "Agrégation", 15h, M2, UPMC

Jean-Frédéric Gerbeau

Numerical methods in hemodynamics (20h), M2, UPMC / Univ Paris-Sud / Ecole Polytechnique.

Seminar for the M2 students of the master “Math SV” (1h), M2, Univ Paris-Sud, December, 2015

Seminar for the Ecole des Mines students (3h), M2, Paris, February, 2015

Thematic schools:

Laurent Boudin

Invited lecturer: "Aerosol in the lung: what mathematics can bring", Univ. Pavia, Italy. 4h. Doctoral level

Miguel Ángel Fernández Varela

Invited lecturer: Summer school on "Control and numerics in fluid-structure interaction problems", TFIR CAM, Bangalore, India, June 22-26, 2015. 10h. Master and doctoral level

Invited lecturer: Autumn School on "Data driven computations in the life sciences", IST, Lisbon, Portugal, November 9-13, 2015. 7,5h. Master and doctoral level

Céline Grandmont

Invited lecturer: Summer school on "Control and numerics in fluid-structure interaction problems", TFIR CAM, Bangalore, India, June 22-26, 2015. 10h. Master and doctoral level

Invited lecturer: CEMRACS "Coupling multi-physics models involving fluids", July 20 - August 28, 2015, CIRM, Marseille. 6h. Master and doctoral level

PhD: Justine Fouchet-Incaux, Mathematical and numerical modeling of the human breathing, Supervisors: C. Grandmont & B. Maury, Defended on April 2015, Orsay.

PhD in progress: Chloé Audebert, *Modeling of liver
hemodynamics*, since October 2013. Supervisors: J.-F. Gerbeau &
I. Vignon-Clementel.

PhD in progress: Francesco Bonaldi, *Modélisation
Mathématique et Numérique de Multi-Structures avec couplage
Magnéto-Electro-Thermo-Elastique*, since October 2013,
Supervisors: F Krasucki & M. Vidrascu

PhD in progress: Mikel Landajuela, *Coupling schemes and
unfitted mesh methods for fluid-structure interaction*, since October
2012, Supervisor: M.A. Fernández Varela.

PhD in progress: Matteo Aletti, *Multiscale retinal vascular modeling* , since January 2014 Supervisors: J.-F. Gerbeau & D. Lombardi.

PhD in progress: Eliott Tixier, *Stem cells electrophysiology*, since September 2014
2014. Supervisors: J-F. Gerbeau & Damiano Lombardi.

PhD in progress : Nicolas Pozin Multiscale lung ventilation modeling in health and disease, since March 2014. Supervisors: C. Grandmont & I. Vignon-Clementel.

PhD in progress : Andrea Bondesan, Kinetic and fluid models, numerical and asymptotic analysis, since October 2015, Supervisors: L. Boudin, B. Grec & S. Martin.

Laurent Boudin

Member of the PhD committee of Justine Fouchet-Incaux, Univ. Paris-Sud, April 2015

Muriel Boulakia

Member of the PhD committee of Gwladys Ravon, Inria Bordeaux Sud-Ouest (referee)

Jean-Frédéric Gerbeau

PhD committees: Francesco Ballarin, Politecnico di Milano (referee); Romain Lacroix, SupTelecom (referee); Alessandra Menafoglio, Politecnico di Milano; Victorien Menier, UPMC (chairman); Simone Palamara, Politecnico di Milano; Alexander Serov, Ecole Polytechnique (referee).

Hiring committee: Inria Rennes (CR2); UTC (Assistant Professor).

Céline Grandmont

Hiring committee: Toulouse Univ. (Professor position), Bordeaux Univ. (Head of the hiring committee, Professor position), Orleans Univ. (Professor position).

Phd Referee: Philipp Nägele, Friburg University, Germany, June 2015

HDR Committee: Muriel Boulakia, UPMC, October 2015

Marc Thiriet

Member of the PhD committee of Sami Hached, Ecole Polytechnique de Montréal (referee)

Member of the PhD committee of Tamara El Bouti, Université de Versailles Saint Quentin en Yvelines (referee)

Member of the PhD committee of Mohammad Haddadi, Université Paris Est–Créteil (referee)

President of thematic comittee CT3 (Biomedical Simulation and Applications to Health) of GENCI (Grand Equipement National de Calcul Intensif – National Large Equipement for Intensive Computation).

Member of Evaluation Groups of the Canadian Granting Agency NSERC

Irène Vignon-Clementel

Member of the PhD committee of Damon Afquari, Universidad Politecnica de Madrid, Spain, December 2015

Member of the PhD committee of Stephanie Lindsey, Cornell University, USA, August 2015

Member of the PhD committee of Tamara El Bouti, Université Versailles Saint Quentin, July 2015

Matteo Aletti

presentation, "Raconte-moi ta thèse", Fête de la science, October 10th, 2015, Paris, France

Chloé Audebert

poster session, Journée "Correspondances", Projet PEPS-égalité "Correspondances de Langlands", April 10th, 2015, Paris, France

presentation, "Raconte-moi ta thèse", Fête de la science, October 10th, 2015, Paris, France

Jessica Oakes

Tutor and mentor to an under-represented minority student struggling in mathematics (1h per week)

SECO: Visit local elementary schools to assist students with hands on science activities (1h per month)

Irène Vignon-Clementel

Intervention at the conference "Research: challenges and adventures", at which the research national strategic plan was presented to the French Prime Minister, in presence of the Minister for Education, Higher Education and Research, Dec 14th., Paris, France
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