REO is a joint project-team of the Inria Research Center of Paris and the Jacques-Louis Lions Laboratory (LJLL) of the Pierre and Marie Curie University (UPMC Paris 6) and CNRS (UMR7598). Its main objectives are:

the modeling of blood flow in large vessels, air flow in the respiratory tract, and the cardiac electrophysiology;

the design and the analysis of efficient and robust numerical methods for these problems;

the development of numerical software to assist medical decisions and to contribute to the design of medical devices.

REO put a strong effort in working with real data, coming either from clinicians or industrial partners. The development of methods for the interaction of data and simulation is therefore an important aspect of the activity of the team.

In large vessels and in large bronchi, blood and air flows are generally supposed to be governed by the incompressible Navier-Stokes equations. Indeed in large arteries, blood can be supposed to be Newtonian, and at rest air can be modeled as an incompressible fluid. The cornerstone of the simulations is therefore a Navier-Stokes solver. But other physical features have also to be taken into account in simulations of biological flows, in particular fluid-structure interaction in large vessels and transport of sprays, particles or chemical species.

Fluid-structure coupling occurs both in the respiratory and in the circulatory systems. We focus mainly on blood flows since our work is more advanced in this field. But the methods developed for blood flows could be also applied to the respiratory system.

Here “fluid-structure interaction” means a coupling between the 3D Navier-Stokes equations and a 3D (possibly thin) structure in large displacements.

The numerical simulations of the interaction between the artery wall and the blood flows raise many issues: (1) the displacement of the wall cannot be supposed to be infinitesimal, geometrical nonlinearities are therefore present in the structure and the fluid problem have to be solved on a moving domain (2) the densities of the artery walls and the blood being close, the coupling is strong and has to be tackled very carefully to avoid numerical instabilities, (3) “naive” boundary conditions on the artificial boundaries induce spurious reflection phenomena.

Simulation of valves, either at the outflow of the cardiac chambers or in veins, is another example of difficult fluid-structure problems arising in blood flows. In addition, very large displacements and changes of topology (contact problems) have to be handled in those cases.

Due to stability reasons, it seems impossible to successfully apply in hemodynamics the explicit coupling schemes used in other fluid-structure problems, like aeroelasticity. As a result, fluid-structure interaction in biological flows raise new challenging issues in scientific computing and numerical analysis : new schemes have to be developed and analyzed.

We have proposed and analyzed over the last few years several efficient fluid-structure interaction algorithms. This topic remains very active. We are now using these algorithms to address inverse problems in blood flows to make patient specific simulations (for example, estimation of artery wall stiffness from medical imaging).

Complex two-phase fluids can be modeled in many different ways. Eulerian models describe both phases by physical quantities such as the density, velocity or energy of each phase. In the mixed fluid-kinetic models, the biphasic fluid has one dispersed phase, which is constituted by a spray of droplets, with a possibly variable size, and a continuous classical fluid.

This type of model was first introduced by Williams
in the frame of combustion. It was later used to develop the Kiva
code at the Los Alamos National Laboratory, or the
Hesione code , for example. It has a wide range of
applications, besides the nuclear setting: diesel engines, rocket
engines , therapeutic sprays, *etc.* One of the
interests of such a model is that various phenomena on the
droplets can be taken into account with an accurate precision:
collision, breakups, coagulation, vaporization, chemical reactions,
*etc.*, at the level of the droplets.

The model usually consists in coupling a kinetic equation, that describes the spray through a probability density function, and classical fluid equations (typically Navier-Stokes). The numerical solution of this system relies on the coupling of a method for the fluid equations (for instance, a finite volume method) with a method fitted to the spray (particle method, Monte Carlo).

We are mainly interested in modeling therapeutic sprays either for local or general treatments. The study of the underlying kinetic equations should lead us to a global model of the ambient fluid and the droplets, with some mathematical significance. Well-chosen numerical methods can give some tracks on the solutions behavior and help to fit the physical parameters which appear in the models.

Multiscale modeling is a necessary step for blood and respiratory flows. In this section, we focus on blood flows. Nevertheless, similar investigations are currently carried out on respiratory flows.

Problems arising in the numerical modeling of the human cardiovascular
system often require an accurate description of the flow in a specific
sensible subregion (carotid bifurcation, stented artery, *etc.*).
The description of such local phenomena is better addressed by means
of three-dimensional (3D) simulations, based on the numerical
approximation of the incompressible Navier-Stokes equations, possibly
accounting for compliant (moving) boundaries. These simulations
require the specification of boundary data on artificial boundaries
that have to be introduced to delimit the vascular district under
study. The definition of such boundary conditions is critical and, in
fact, influenced by the global systemic dynamics. Whenever the
boundary data is not available from accurate measurements, a proper
boundary condition requires a mathematical description of the action
of the reminder of the circulatory system on the local district. From
the computational point of view, it is not affordable to describe the
whole circulatory system keeping the same level of detail. Therefore,
this mathematical description relies on simpler models, leading to the
concept of *geometrical multiscale* modeling of the circulation
. The underlying idea consists in coupling
different models (3D, 1D or 0D) with a decreasing level of accuracy,
which is compensated by their decreasing level of computational
complexity.

The research on this topic aims at providing a correct methodology and a mathematical and numerical framework for the simulation of blood flow in the whole cardiovascular system by means of a geometric multiscale approach. In particular, one of the main issues will be the definition of stable coupling strategies between 3D and reduced order models.

To model the arterial tree, a standard way consists of imposing a
pressure or a flow rate at the inlet of the aorta, *i.e.* at the
network entry. This strategy does not allow to describe important
features as the overload in the heart caused by backward traveling
waves. Indeed imposing a boundary condition at the beginning of the
aorta artificially disturbs physiological pressure waves going from
the arterial tree to the heart. The only way to catch this
physiological behavior is to couple the arteries with a model of
heart, or at least a model of left ventricle.

A constitutive law for the myocardium, controlled by an electrical
command, has been developed in the CardioSense3D project

A long term goal is to achieve 3D simulations of a system including heart and arteries. One of the difficulties of this very challenging task is to model the cardiac valves. To this purpose, we investigate a mix of arbitrary Lagrangian Eulerian and fictitious domain approaches or x-fem strategies, or simplified valve models based on an immersed surface strategy.

The heart is the organ that regulates, through its periodical contraction, the distribution of oxygenated blood in human vessels in order to nourish the different parts of the body. The heart needs its own supply of blood to work. The coronary arteries are the vessels that accomplish this task. The phenomenon by which blood reaches myocardial heart tissue starting from the blood vessels is called in medicine perfusion. The analysis of heart perfusion is an interesting and challenging problem. Our aim is to perform a three-dimensional dynamical numerical simulation of perfusion in the beating heart, in order to better understand the phenomena linked to perfusion. In particular the role of the ventricle contraction on the perfusion of the heart is investigated as well as the influence of blood on the solid mechanics of the ventricle. Heart perfusion in fact implies the interaction between heart muscle and blood vessels, in a sponge-like material that contracts at every heartbeat via the myocardium fibers.

Despite recent advances on the anatomical description and measurements of the coronary tree and on the corresponding physiological, physical and numerical modeling aspects, the complete modeling and simulation of blood flows inside the large and the many small vessels feeding the heart is still out of reach. Therefore, in order to model blood perfusion in the cardiac tissue, we must limit the description of the detailed flows at a given space scale, and simplify the modeling of the smaller scale flows by aggregating these phenomena into macroscopic quantities, by some kind of “homogenization” procedure. To that purpose, the modeling of the fluid-solid coupling within the framework of porous media appears appropriate.

Poromechanics is a simplified mixture theory where a complex
fluid-structure interaction problem is replaced by a superposition of
both components, each of them representing a fraction of the complete
material at every point. It originally emerged in soils mechanics with
the work of Terzaghi , and Biot later
gave a description of the mechanical behavior of a porous medium using
an elastic formulation for the solid matrix, and Darcy's law for the
fluid flow through the matrix. Finite strain poroelastic models have
been proposed (see references in ), albeit with *ad hoc* formulations for which compatibility with thermodynamics laws and incompressibility conditions is not established.

The same way the myocardium needs to be perfused for the heart to beat, when it has reached a certain size, tumor tissue needs to be perfused by enough blood to grow. It thus triggers the creation of new blood vessels (angiogenesis) to continue to grow. The interaction of tumor and its micro-environment is an active field of research. One of the challenges is that phenomena (tumor cell proliferation and death, blood vessel adaptation, nutrient transport and diffusion, etc) occur at different scales. A multi-scale approach is thus being developed to tackle this issue. The long term objective is to predict the efficiency of drugs and optimize therapy of cancer.

We aim at developing a multiscale model of the respiratory tract. Intraprenchymal airways distal from generation 7 of the tracheabronchial tree (TBT), which cannot be visualized by common medical imaging techniques, are modeled either by a single simple model or by a model set according to their order in TBT. The single model is based on straight pipe fully developed flow (Poiseuille flow in steady regimes) with given alveolar pressure at the end of each compartment. It will provide boundary conditions at the bronchial ends of 3D TBT reconstructed from imaging data. The model set includes three serial models. The generation down to the pulmonary lobule will be modeled by reduced basis elements. The lobular airways will be represented by a fractal homogenization approach. The alveoli, which are the gas exchange loci between blood and inhaled air, inflating during inspiration and deflating during expiration, will be described by multiphysics homogenization.

Cardiovascular diseases like atherosclerosis or aneurysms are a major cause of mortality. It is generally admitted that a better knowledge of local flow patterns could improve the treatment of these pathologies (although many other biophysical phenomena obviously take place in the development of such diseases). In particular, it has been known for years that the association of low wall shear stress and high oscillatory shear index give relevant indications to localize possible zones of atherosclerosis. It is also known that medical devices (graft or stent) perturb blood flows and may create local stresses favorable with atherogenesis. Numerical simulations of blood flows can give access to this local quantities and may therefore help to design new medical devices with less negative impacts. In the case of aneurysms, numerical simulations may help to predict possible zones of rupture and could therefore give a guide for treatment planning.

In clinical routine, many indices are used for diagnosis. For example, the size of a stenosis is estimated by a few measures of flow rate around the stenosis and by application of simple fluid mechanics rules. In some situations, for example in the case a sub-valvular stenosis, it is known that such indices often give false estimations. Numerical simulations may give indications to define new indices, simple enough to be used in clinical exams, but more precise than those currently used.

It is well-known that the arterial circulation and the heart (or more specifically the left ventricle) are strongly coupled. Modifications of arterial walls or blood flows may indeed affect the mechanical properties of the left ventricle. Numerical simulations of the arterial tree coupled to the heart model could shed light on this complex relationship.

One of the goals of the REO team is to provide various models and simulation tools of the cardiovascular system. The scaling of these models will be adapted to the application in mind: low resolution for modeling the global circulation, high resolution for modeling a small portion of vessel.

Breathing, or “external” respiration (“internal” respiration corresponds to cellular respiration) involves gas transport though the respiratory tract with its visible ends, nose and mouth. Air streams then from the pharynx down to the trachea. Food and drink entry into the trachea is usually prevented by the larynx structure (epiglottis). The trachea extends from the neck into the thorax, where it divides into right and left main bronchi, which enter the corresponding lungs (the left being smaller to accommodate the heart). Inhaled air is then convected in the bronchus tree which ends in alveoli, where gaseous exchange occurs. Surfactant reduces the surface tension on the alveolus wall, allowing them to expand. Gaseous exchange relies on simple diffusion on a large surface area over a short path between the alveolus and the blood capillary under concentration gradients between alveolar air and blood. The lungs are divided into lobes (three on the right, two on the left) supplied by lobar bronchi. Each lobe of the lung is further divided into segments (ten segments of the right lung and eight of the left). Inhaled air contains dust and debris, which must be filtered, if possible, before they reach the alveoli. The tracheobronchial tree is lined by a layer of sticky mucus, secreted by the epithelium. Particles which hit the side wall of the tract are trapped in this mucus. Cilia on the epithelial cells move the mucous continually towards the nose and mouth.

Each lung is enclosed in a space bounded below by the diaphragm and
laterally by the chest wall and the mediastinum. The air movement is
achieved by alternately increasing and decreasing the chest pressure
(and volume). When the airspace transmural pressure rises, air is
sucked in. When it decreases, airspaces collapse and air is expelled.
Each lung is surrounded by a pleural cavity, except at its hilum where
the inner pleura give birth to the outer pleura. The pleural layers
slide over each other. The tidal volume is nearly equal to 500

The lungs may fail to maintain an adequate supply of air. In premature infants surfactant is not yet active. Accidental inhalation of liquid or solid and airway infection may occur. Chronic obstructive lung diseases and lung cancers are frequent pathologies and among the three first death causes in France.

One of the goals of REO team in the ventilation field is to visualize the airways (virtual endoscopy) and simulate flow in image-based 3D models of the upper airways (nose, pharynx, larynx) and the first generations of the tracheobronchial tree (trachea is generation 0), whereas simple models of the small bronchi and alveoli are used (reduced-basis element method, fractal homogenization, multiphysics homogenization, lumped parameter models), in order to provide the flow distribution within the lung segments.

The purpose is to simulate the propagation of the action potential in the heart. A lot of works has already been devoted to this topic in the literature (see *e.g.* , , and the references therein), nevertheless there are only very few studies showing realistic electrocardiograms obtained from partial differential equations models. Our goal is to find a compromise between two opposite requirements: on the one hand, we want to use predictive models, and therefore models based on physiology, on the other hand, we want to use models simple enough to be parametrized (in view of patient-specific simulations). One of the goal is to use our ECG simulator to address the inverse problem of electrocardiology. In collaboration with the MACS/M3DISIM project-team, we are interested in the electromechanical coupling in the myocardium. We are also interested in various clinical and industrial issues related to cardiac electrophysiology, in particular the simulation of experimental measurement of the field potential of cardiac stem cells in multi-electrode arrays.

An important industrial partnership has been signed with the start-up companies Kephalios and Epygon, for the mathematical modeling of implantable cardiac devices.

Keywords: Cardiac Electrophysiology - Safety Pharmacology

Functional Description

cardioXcomp is a software dedicated to the safety pharmacology industry. It is developed in the framework of the joint laboratory (LabCom) “cardioXcomp” with the software company Notocord. Its purpose is to model the electrical potential of cardiomyocytes measured by a microelectrode array (MEA), and to model the effect of drugs on this signal. It was registered in November 2015 at the Agence pour la Protection des Programmes under the Inter Deposit Digital Number IDDNFR.001.480003.000.S.P.2015.000.31230.

Participants: Jean-Frédéric Gerbeau, Fabien Raphel, Nejib Zemzemi

Contact: Jean-Frédéric Gerbeau

Finite Elements for Life SCiences and Engineering problems

Keywords: Finite element modeling - Cardiac Electrophysiology - Cardiovascular and respiratory systems

Functional Description

FELiScE is a finite element code which the M3DISIM and REO project-teams have decided to jointly develop in order to build up on their respective experiences concerning finite element simulations. One specific objective of this code is to provide in a unified software environment all the state-of-the-art tools needed to perform simulations of the complex respiratory and cardiovascular models considered in the two teams – namely involving fluid and solid mechanics, electrophysiology, and the various associated coupling phenomena. FELISCE is written in C++, and may be later released as an opensource library. FELiScE was registered in July 2014 at the Agence pour la Protection des Programmes under the Inter Deposit Digital Number IDDN.FR.001.350015.000.S.P.2014.000.10000.

Participants: Dominique Chapelle, Miguel Ángel Fernández Varela, Jean-Frédéric Gerbeau, Philippe Moireau, Marina Vidrascu, Sebastien Gilles, Benoit Fabreges, Axel Fourmont, Mikel Landajuela Larma, Damiano Lombardi, Matteo Aletti, Irene Vignon-Clementel and Faisal Amlani

Contact: Jean-Frédéric Gerbeau

Functional Description

MODULEF is a legacy finite element library developed at Inria since the 1980's. Here, we limit ourselves to recent developments done within this library.

A numerical method to approximate the constitutive laws for rubber elasticity derived from polymer physics are implemented in Modulef.

It is based on algorithms from stochastic geometry to generate suitable polymer networks, Delaunay tessellation algorithms to deal with steric effects (courtesy of the Inria project-team GAMMA2), the introduction of 1-dimensional finite elements for the polymer-chains in Modulef.

Participants: Marina Vidrascu and Antoine Gloria

Contact: Marina Vidrascu

SHELls and structural Dynamics with DOmain decomposition in Nonlinear analysis

Functional Description

SHELDDON is a finite element library based on the Modulef package which contains shell elements, nonlinear procedures and PVM subroutines used in domain decomposition or coupling methods, in particular fluid-structure interaction.

Participants: Dominique Chapelle, Patrick Le Tallec and Marina Vidrascu

Contact: Marina Vidrascu

In , we explain with a 0D closed-loop lumped model the hemodynamics changes observed during partial hepatectomy in pigs . The typical increase of portal pressure, increase of liver pressure loss, slight decrease of portal flow and major decrease in arterial flow are quantitatively captured by the model for a 75% hepatectomy. The different post-operative states, observed in experiments, are reproduced with the proposed model. Thus, an explanation for inter-subjects post-operative variability is proposed. This work needs to be translated to humans, in which liver flow modulation is a subject of surgery research .

Peripheral pulmonary artery stenosis (PPS) is a congenital abnormality resulting in pulmonary blood flow disparity and right ventricular hypertension, for which optimal surgical strategies remain unclear. In , a proof of concept study, a constant shear stress hypothesis and structured pulmonary trees are used to derive adaptive outflow boundary conditions for 3D-0D postoperative blood flow simulations. This strategy provides better predictions of pulmonary flow distribution than the conventional strategy of maintaining outflow boundary conditions.

CIFRE convention and contract with Air Liquide Santé International in the context of the ANRT on “Multiscale lung ventilation modeling in health and disease”, for the PhD thesis of Nicolas Pozin (March 2014 - February 2017).

CIFRE convention and contract with Philips Research for the PhD thesis of Alexandre This (January 2016 - December 2018) on fusion data/simulation for the assessment of mitral regurgitation.

REO is an academic partner of the industrial project MIVANA, dedicated to the development of new technologies for mitral valve treatment. It is led by the start-up company Kephalios, with the participation of the start-up company Epygon, by the company MDB Texinov and the research institute IFTH. In this framework, REO has two bilateral contracts with Kephalios and Epygon on the modeling and simulation of two medical devices for mitral valve repair.

REO partners with the software company NOTOCORD in the framework of the LabCom “cardioXcomp” (see ANR projects section). In 2016, the ANR funding came to an end, and NOTOCORD was acquired by the company Instem. Our collaboration with Instem/NOTOCORD will continue as a bilateral partnership with the purpose of developing the software cardioXcomp dedicated to the safety pharmacology industry.

Period: 2012-2016

The aim of this project, coordinated by Miguel Ángel Fernández Varela, is to study mathematically and numerically new numerical methods for incompressible fluid-structure interaction.

Period: 2013-2016.

This project, coordinated by Jean-Frédéric Gerbeau, is carried out in the framework of a joint laboratory (“LabCom” call of ANR) with the software company NOTOCORD. The focus is the mathematical modeling of a device measuring the electrical activity of cardiomyocytes. The overall objective of CardioXcomp is to enrich NOTOCORD's software with modeling and simulation solutions and provide to safety pharmacology research a completely new set incorporating state of the art signal processing and numerical simulation.

Period: 2013-2017.

This ANR-TecSan, co-managed by Eric Vibert (Paul Brousse Hospital) and Irene Vignon-Clementel, aims at developing an Intraoperative Fluorescent Liver Optimization Workflow to better understand the relationship between architecture, perfusion and function in hepatectomy.

Other partners: DHU Hepatinov - Hôpital Paul Brousse, Inria Mamba, Fluoptics, IfADo, MID.

Period: 2015-2019.

The objective of this project, coordinated by Takéo Takahashi (Inria Nancy Grand-Est), is the mathematical analysis of systems involving structures immersed in a fluid. This includes the asymptotic analysis, the study of the controllability and stabilization of fluid-structure interaction systems, the understanding of the motion of self-propelled structures and the analysis and development of numerical methods to simulate fluid-structure systems.

Laurent Boudin is a member of the ANR Blanc project Kibord on kinetic models in biology and related domains

Laurent Boudin is a member of the ANR TecSan Oxhelease

Céline Grandmont is a member of the ANR TecSan Oxhelease

Marina Vidrascu is a member of the ANR ARAMIS

Irene Vignon-Clementel is a member of the project iLite (09/16-), RHU-santé grant, a large French hospital-medical research consortium that aims at developing innovations for liver and tissue engineering (Inria PI: Dirk Drasdo).

Period: 2014-2016

The aim of this project, coordinated by Miguel Ángel Fernández Varela, is to implement in the FELiScE library the shell elements included in the shelddon and Modulef libraries.

Period: 2016-2017

The aim of this project, coordinated by Miguel Ángel Fernández Varela, is to implement in the FELiScE library several balancing domain decomposition methods (BDD) for solid-mechanics.

Title: "Retinal Vascular Modeling, Measurement and Diagnosis"

Programm: FP7

Duration: April 2013 - March 2017

Coordinator: University of Lincoln

Partners: See the web site http://

Inria contact: J.-F. Gerbeau

REVAMMAD is a European Union project aimed at combatting some of the EU’s most prevalent chronic medical conditions using retinal imaging. The project aims to train a new generation of interdisciplinary scientists for the academic, clinical and industrial sectors, and to trigger a new wave of biomedical interventions. The role of REO team within this consortium is to propose a mathematical model and a simulation tool for the retina hemodynamics. See http://

Action MP1404, a pan-European network of experts in the field of inhaled medicine

Period: 2010-2016

This network, funded by the Leducq foundation, is working on the multi-scale modeling of single ventricle hearts for clinical decision support.

Other partners: see http://

Visiting Professor: Rodolfo Araya, University of Concepcion (Chile), from Apr 2016 to Jul 2016

Visiting PhD student: Michele Annese, Universita degli Studi di Brescia (Italy), from Mar to Jul 2016

Visiting PhD student: Stefano Zonca, Politecnico di Milano (Italy), from Oct to Sep 2016

Matteo Aletti

Co-organizer of the monthly Junior Seminar of Inria Paris.

Laurent Boudin

Member of the organizing and scientific committees of the "Recent advances in kinetic equations and applications" workshop, June 2016, Paris

Member of the organizing committee of the 5th "Forum Emploi Maths", December 2016, Paris

Jean-Frédéric Gerbeau

Local organizing Committee of the SIAM conference on Parallel Processing 2016. Paris, France.

Sanjay Pant

Organizing committee member, 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE) 2017

I. Vignon-Clementel

Organized a minisymposium at the COSINE conference, May 25th-26th, Bordeaux, France

Organized a minisymposium at the ECCOMAS congress, June 4th-9th, Crete, Greece

Programme committee member, Computational and Mathematical Biomedical Engineering Conference

Conference steering committee, International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease, 2015-present

Jean-Frédéric Gerbeau

Member of the Scientific Program Committee of the Millennium Science Initiative, a program of the Ministry of Economy of Chile.

Expert for Horizon2020 FET OPEN RIA Call 2015/2.

Irene Vignon-Clementel

Expert for “Appel à projets générique”, ANR 2016.

Marina Vidrascu

Expert for FONDECYT - Chile “Projects for Initiation in Research” 2016

Jean-Frédéric Gerbeau

Editor-in-Chief of Mathematical Modelling and Numerical Analysis (M2AN), SMAI/EDP Sciences.

Series editor of “SEMA SIMAI Series”, Springer.

Member of the editorial board of Journal Advances in Computational Mathematics (ACOM), Springer

Member of the editorial board of International Journal for Numerical Methods in Biomedical Engineering (IJNMBE), Wiley.

Member of the editorial board of Communications in Applied and Industrial Mathematics, SIMAI/De Gruyter.

Member of the editorial board of Journal for Modeling in Ophthalmology, Kugler.

Marc Thiriet

Member of the editorial board of Digital Medicine

Laurent Boudin

Expert evaluator for ANVUR (VQR 2011-2014), Italy

Member of the Board of Mathematics Licence (EFU de Licence de mathématiques), UPMC

Member of the think-tank for third-year programs in Mathematics at UPMC.

Member of the IREM (Institutes for Research on Mathematics Teaching) Scientific Committee.

Member of the SMAI (French Society for applied and industrial mathematics) Teaching Committee.

Muriel Boulakia

Supervisor of the teaching of mathematics at the engineer school Polytech Paris-UPMC

Miguel Ángel Fernández Varela

Co-president of the Scientific Positions Commission, Inria Paris

Jean-Frédéric Gerbeau

Service activity at Inria: Délégué Scientifique / Chairman of the project-teams' committee of Inria Paris research center; Member of the Inria Evaluation Committee.

Service activity in other French institutions: member of the scientific committee of Labex NUMEV, Montpellier.

Service activity abroad: member of the Reference Committee of the PhD program Mathematical Models and Methods in Engineering (Politecnico di Milano, Italy).

Céline Grandmont

Member of the Evaluation Committee Inria (2015–)

Head of the HCERES evaluation Jury of Imath lab. Toulon Univ.

Marc Thiriet

Vice-President & Council Member of the International Society of Digital Medicine

I. Vignon-Clementel

Organizing the monthly seminar at Inria Paris on “modeling and scientific computing”, now joint seminar "Rencontres Inria-LJLL en calcul scientifique" (until June 2016)

Committee member for PhD students at Inria "Commission consultative des doctorants", since July 2016.

Mediator between PhD students and their supervisors for Inria Paris-Rocquencourt

Matteo Aletti

Minisymposium talk, SIMAI2016, Sep 13-16, 2016 Milano, Italy

Minisymposium talk, ECCOMAS Congress 2016, Jun 5-10, 2016, Crete, Greece

Presentation at REVAMMAD (EU Marie Curie ITN) meeting, Jun 2016, Lincoln, UK

Rodolfo Araya

Seminar, Laboratoire de Mathématiques de Besançon, Université de Franche-Comté, Besançon, May 26

Seminar, Groupe de Modélisation Mathématique, Mécanique et Numérique, Université de Caen Basse-Normandie, Jun 6

Minisymposium talk, The Mathematics of Finite Elements and Applications 2016 (MAFELAP 2016) conference, Jun 14-17, London, UK

Chloé Audebert

Seminar, Journée interne du Laboratoire Jacques-Louis Lions, Nov 16, 2016, Paris, France.

Seminar, BioMécanique et BioIngénierie (BMBI), UTC, Nov 15, 2016, Compiègne, France.

Minisymposium talk,Word Congress on Computational Mechanics (WCCM), Jul 24-29, 2016, Seoul, Korea

Minisymposium talk, European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS), Jun 5-10, 2016, Crete Island, Greece

Open Brain in HPB Surgery, Club Innovation ACHBT, Jun 3-5, 2016, Carnac, France.

Congrès National d’Analyse Numérique (CANUM), May 9-13, 2016, Obernai, France

Talk, Saint-Antoine hospital, May 3, 2016, Paris, France

Laurent Boudin

Seminar, Applied Mathematics, Department of Mathematics and Informatics, Univ. Novi Sad, Serbia, July 2016

Muriel Boulakia

Workshop ANR IFSMACS, Toulouse, Nov 2016

Invited talk, Workshop Carleman estimates, unique continuation, University College of London, Nov 2016

Seminar LMAC, Compiègne, Oct 2016

Workshop Mathematics and Health, LJLL, UPMC, May 2016

Workshop ANR IFSMACS, Paris, Mar 2016

Seminar PDE, IECL, Nancy, Feb 2016

Miguel Ángel Fernández Varela

Invited Speaker IWH Symposium on Simulation and Optimization of Extreme Fluids, Oct 2016, Heidelberg, Germany

Minisymposium talk, The Mathematics of Finite Elements and Applications 2016 (MAFELAP 2016) conference, Jun 14-17, London, UK

Invited Speaker, Workshop on geometrically unfitted finite element methods, Jan 6-8, 2016, London, UK

Jean-Frédéric Gerbeau

Invited lecturer, CISM-ECCOMAS International Summer School (6 hours), June 2016, Udine, Italia.

Invited lecturer, “Numerical methods for PDEs”, Institut Henri Poincaré (9 hours), Oct 2016, Paris, France.

Invited speaker, Workshop: Mathematical Modeling in Cardiovascular Healthcare, Oct 2016, Emory University, USA

Invited speaker, Workshop “Boundary layer and Fluid-Structure Interaction”, Jan 2016, Bordeaux, France.

Invited speaker, 2d conference “Mathematical Modelling of Complex Systems”, Dec 2016, Châtenay Malabry, France.

Seminar at Collège de France, Pierre-Louis Lions chair, May 2016, Paris, France.

Minisymposium talk, European Congress of Mathematics (ECM), July 2016, Berlin, Germany.

Minisymposium talk, World Congress of Computational Mechanics (WCCM), July 2016, Seoul, Korea.

Minisymposium talk, SIMAI conference, Sep 2016, Milan, Italy.

Céline Grandmont

Invited Speaker IWH Symposium on Simulation and Optimization of Extreme Fluids, Oct 2016, Heidelberg, Germany

Seminar, Ecole Centrale, Apr 2016

Invited Speaker, Journées Jeunes Edépistes, Mar 2016, Bordeaux

Invited Speaker, Boundary Layers and Fluid-Structure Interactions, Jan 2016, Bordeaux

Mikel Landajuela

Seminar, Séminaire d’analyse numérique, Université de Genève, Mar 8, 2016, Geneva, Switzerland

Damiano Lombardi

Invited talk, ALGORITMY 2016, Mar 13-18, 2016, Podbaske, Slovakia

Invited talk, SIMAI 2016, Sep 13-16, 2016, Milano, Italy

Contributed talk, Workshop on Reduced Order Modeling, Nov 7-10, 2016, Institut Henri Poincaré, Paris

Sanjay Pant

Contributed talk, The 12th World Congress on Computational Mechanics (WCCM XII), Jul 2016, Seoul, Korea

Contributed talk, 5th International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease, Jun 2016 , Orlando, Florida, USA

Contributed talk, Computational modeling in healthcare: Making confident predictions in a world of error and uncertainty, Apr 2016, Glasgow, UK

Nicolas Pozin

Minisymposium talk, European Congress on Computational Methods in Applied Sciences and Engineering - ECCOMAS 2016, Jun 5-10, 2016, Creta, Greece

Marc Thiriet

Invited Speaker, 6th Annual Academic Congress of Chinese Society of Digital Medicine and1st International Conference on Digital Medicine & Medical 3D Printing, Jun 17-19, 2016, Nanjing, China

Minisymposium talk, 16th International Society for Therapeutic Ultrasound (ISTU), Mar 14-16, 2016, Tel-Aviv, Israel

Alexandre This

Seminar, Inria Paris Junior Seminar, Oct 18, 2016, Paris

Eliott Tixier

Minisymposium talk, SIAM Conference on Uncertainty Quantification, Apr 5-8, 2016, Lausanne, Switzerland

Irene Vignon-Clementel

Seminar, Paul Brousse Hospital, Nov 18th, Villejuif, France

Seminar, DKFZ, Nov 15th, Heidelberg, Germany

Invited talk, SimInhale workshop, Oct 17th-19th, Prague, Czech Republic

Invited talk, GRIC Journées Françaises de Radiologie, Oct 13th, Paris, France

Minisymposium talk, CMBBE conference, September 20th-22nd, Tel Aviv, Israel

Seminar, Dassault Systems, July 20th, Velizy-Villacoublay, France

Minisymposium talk, SIAM Conference on the Life Sciences, July 11th-14th, Boston, USA

Presentation for the Chinese Academy of Science, June 29th, Paris, France

Invited talk, Inria National Scientific Days, June 20th-22th, Rennes, France

Invited talk, International Conference on Engineering Frontiers in Pediatric and Congenital Heart Disease, June 9th-10th, Orlando, USA

Minisymposim Keynote, ECCOMAS congress, June 4th-9th, Crete, Greece

Minisymposium talk, COSINE conference, May 25th-26th, Bordeaux, France

Presentation, Demi-journée Math-Industrie, LJLL-UPMC, May 10th 2016, Paris, France

Invited Keynote, Computational modelling in healthcare: Making confident predictions in a world of error and uncertainty (workshop), April 26th 2016, Glasgow, UK

Minisymposium talk, UQ SIAM conference, EPFL, April 5th-8th, 2016, Lausanne, Switzerland

Invited talk, workshop: towards a unified framework for benchmarking multicellular models and modelling/simulation software, Leipzig University, March 14th-16th, 2016, Leipzig, Germany

Podium talk, The 8th International Bio-Fluids Symposium, February 12-14, 2016, CaltechTech, Pasadena, USA

Seminar, Department of Mechanical Eng., UC at Berkeley, Feb. 10th, 2016, Berkeley, USA

Seminar, HeartFlow company, Feb. 9th, 2016, Mountain View, USA

Licence :

Ludovic Boilevin-Kayl

Calculus, 60h, L1, UPMC

Laurent Boudin

Introduction to series for signal theory, 18h, L2, UPMC

Shared studies supervision in mathematics licence for approximately 500 students, 48h, L2-L3, UPMC

Muriel Boulakia

Scilab, 35h, L2, UPMC

Nonlinear systems and optimization, 35h, L3, Polytech'Paris

Hilbertian analysis, 50h, L3, Polytech'Paris

Oral tests in numerical analysis, 20h, L3, UPMC

Miguel Ángel Fernández Varela

Analysis and Scientific Computing, 30h, L3, ENPC

Jean-Frédéric Gerbeau

Numerical Analysis and Optimization, 32h, L3, Ecole Polytechnique.

Céline Grandmont

Ordinary differential equations, 24h, L3, UPMC

Damiano Lombardi

Numerical Methods, 48h, L3, Polytech'Paris

Eliott Tixier

Linear algebra, 60h, L2, Polytech'Paris

Irene Vignon-Clementel

Mathematics for biology, 54h, L1, Université de Versailles Saint Quentin

Numerical simulations of blood flow, 1h30, as part of the undergraduate "continuum mechanics", AgroParisTech

Master :

Laurent Boudin

Basics for numerical methods, 36h, M1, UPMC

Muriel Boulakia

Preparatory course for teaching admission examination "Agrégation", 15h, M2, UPMC

Miguel Ángel Fernández Varela

Numerical methods for bio-fluids simulation, 9h, M2, Universidade de Vigo, Spain

Irene Vignon-Clementel

Modélisation hémodynamique & simulation numérique comme outil pour la chirurgie, 1h, M2, Université Paris Sud

Jean-Frédéric Gerbeau

Numerical methods in hemodynamics (20h), M2, UPMC / Univ Paris-Sud / Ecole Polytechnique.

Seminar for M2 students of the master “Math SV” (1h), M2, Univ Paris-Sud, December, 2015

Seminar for M2 students at Ecole des Mines (3h), Paris, February, 2015

HdR : Irene Vignon-Clementel, *Blood and air flow multi-scale simulations based on real data*, defended on March 31, 2016

PhD in progress: Chloé Audebert, *Modeling of liver hemodynamics*, since October 2013. Supervisors: J.-F. Gerbeau & I. Vignon-Clementel.

PhD : Francesco Bonaldi, *Modélisation Mathématique et Numérique de Multi-Structures avec couplage
Magnéto-Electro-Thermo-Elastique*, defended on July 6, 2016. Supervisors: F. Krasucki & M. Vidrascu

PhD : Mikel Landajuela, *Coupling schemes and
unfitted mesh methods for fluid-structure interaction*, defended in March 29, 2016. Supervisor: M.A. Fernández Varela.

PhD in progress: Matteo Aletti, *Multiscale retinal vascular modeling*, since January 2014. Supervisors: J.-F. Gerbeau & D. Lombardi.

PhD in progress: Eliott Tixier, *Stem cells electrophysiology*, since September 2014. Supervisors: J-F. Gerbeau & D. Lombardi.

PhD in progress: Nicolas Pozin, *Multiscale lung
ventilation modeling in health and disease*, since March 2014. Supervisors: C. Grandmont & I. Vignon-Clementel.

PhD in progress: Andrea Bondesan, *Kinetic and fluid
models, numerical and asymptotic analysis*, since October
2015. Supervisors: L. Boudin, B. Grec & S. Martin.

PhD in progress: Ludovic Boilevin-Kayl, *Modeling of cardiac implantable devices*,
since February 2016. Supervisors: J.-F. Gerbeau & M.A. Fernández Varela

PhD in progress: Alexandre This, *Fusion data/simulation for the assessment of mitral regurgitation*,
since January 2016. Supervisor: J.-F. Gerbeau

PhD in progress: Chen-Yu Chiang, *Transport on biological systems and some applications*, since February 2016. Supervisor: M. Thiriet

Laurent Boudin

PhD committee: Alexandra de Cecco, Université Paul Sabatier (referee), Anthony Preux, Université Paris-Saclay

Muriel Boulakia

PhD committee: Andjela Davidovic, Inria Bordeaux Sud-Ouest; Ibtissem Ben Aïcha, Université d’Aix-Marseille

Miguel Ángel Fernández Varela

PhD committee: Moctar Ndiaye, Université Paul Sabatier (president), Davide Baroli, Politecnico di Milano, Simone Brugiapaglia, Politecnico di Milano; Rocco M. Lancellotti, Politecnico di Milano (referee); Paolo Pacciarini, Politecnico di Milano

Jean-Frédéric Gerbeau

PhD committees: Julien Sigüenza, Univ Montpellier (referee). Anna Tagliabue, Politecnico di Milano (referee).

Hiring committee: Inria Bordeaux (CR2); Inria Paris (CR2).

Céline Grandmont

Hiring committee: Rennes Univ. (Professor position), Marseille Univ. (Professor position)

PhD committee: M. Ndiaye, Université Paul Sabatier (president), B. Polizzi, Univ. de Nice (referee), B. Burtschell, Ecole Polytechnique (referee), P. Jounieaux, UPMC (president)

Member of the «Agrégation» Jury in mathematics

Marc Thiriet

PhD committee: M. Haddadi, Université Paris Est–Créteil (referee)

Marina Vidrascu

PhD committee: F. Bonaldi, Université de Montpellier; M Hédi, Tunis El-Manar & UPMC; F. Cheick, Tunis El-Manar & UPMC

Irene Vignon-Clementel

PhD committee: Gabrielle Fournet, CEA & Université Paris-Saclay (referee)

Céline Grandmont

Conference : "Filles et Maths : une équation lumineuse", 60 students secondary school level, Feb 2016

Popularization paper with J.-F. Gerbeau : "Maths, médecine et entreprises : des collaborations gagnantes", brochure Maths Société Express, 2016

Conference "Métier": Master 1 Maths students, UPMC, Nov 2016

Irene Vignon-Clementel

Telerama, Interview (Richard Senejoux), Mar 10, 2016

Presentation, Inauguration of Inria Paris research center in presence of the Minister of Research and presidents of Universities, ANR, EPST, media, etc. Mar 10, 2016, Paris

High school conference, Mar 14, 2016, Lycée St François d'Assise, Montigny le Bretonneux