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Section: New Software and Platforms
AuReMe
Automatic Reconstruction of Metabolic networks
Keywords: Workflow - Bioinformatics - Metabolic networks - Omic data - Toolbox - Data management
Functional Description: AuReMe enables the reconstruction of metabolic networks from different sources based on sequence annotation, orthology, gap-filling and manual curation. The metabolic network is exported as a local wiki allowing to trace back all the steps and sources of the reconstruction. It is highly relevant for the study of non-model organisms, or the comparison of metabolic networks for different strains or a single organism.
Five modules are composing AuReMe: 1) The Model-management PADmet module allows manipulating and traceing all metabolic data via a local database. 2) The meneco python package allows the gaps of a metabolic network to be filled by using a topological approach that implements a logical programming approach to solve a combinatorial problem 3) The shogen python package allows genome and metabolic network to be aligned in order to identify genome units which contain a large density of genes coding for enzymes, it also implements a logical programming approach. 4) The manual curation assistance PADmet module allows the reported metabolic networks and their metadata to be curated. 5) The Wiki-export PADmet module enables the export of the metabolic network and its functional genomic unit as a local wiki platform allowing a user-friendly investigation.
News Of The Year: (1) Creation of a python package for the multiprocessing of Pathway-Tools. (2) Moving from Python 2 to Python 3. (3) Application of AuReMe to microbiome reconstructions and wikis.
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Participants: Marie Chevallier, Meziane Aite, Guillaume Collet, Nicolas Loira, Sylvain Prigent, Jeanne Got, Anne Siegel and Alejandro Maass
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Publication: Traceability, reproducibility and wiki-exploration for ”à-la-carte” reconstructions of genome-scale metabolic models