Section: Overall Objectives

Overall Applied Objectives

Data are generated in clinical trials or biological experimentations. Our main application of interest is the immune response to vaccines or other immune interventions (such as exogenous cytokines), in the context of HIV or Ebola infection. The methods developed in this context can be applied in other circumstances but the focus of the team on immunology and vaccinology is important for the relevance of the results and their translation into practice, thanks to a longstanding collaboration with several immunologists and the implication of the team in the Labex Vaccine Research Institute (http://vaccine-research-institute.fr). Examples of objectives related to this application field are:

• To understand how immune responses are generated with immune interventions (vaccines or immunotherapies)

• To predict what would be the immune responses to a given immune intervention in order to design next studies and to adapt interventions to individual persons or to specific populations