Section: Partnerships and Cooperations

National Initiatives

Cardiac imaging project

Participants : Jean-Yves Gauvrit, Christian Barillot, Elise Bannier.

duration : from 04/10/2011

A proposal led by the Cardiology Department of the University Hospital of Rennes in collaboration with the Radiology Department, the University of Rennes 1 and the Neurinfo platform was granted by the Fédération Française de Cardiologie in order to acquire an advanced MRI software specific to cardiac imaging ("Advanced Cardiac #3T"). This software, installed in October 2011, will enable the development of local cardiac imaging projects in close collaboration with cardiologists and cardio-radiologists. It will also increase the capacity of the Neurinfo platform to take part into external clinical reseach studies involving cardiac imaging.

Apathy in depression: neural basis from perfusion and functional MR

Participants : Jean-Christophe Ferré, Christian Barillot, Isabelle Corouge, Elise Bannier.

duration : 18 months from 01/07/2011

Depression is becoming a major cause of handicap due to its relapses and chronicity. The main risk factors for relapse are residual symptoms like apathy. Apathy is defined as a decrease in motivation and expresses itself on the behavorial, cognitive and emotional levels. However, the neural basis of apathy remain unknown. This project proposes 1) to use Arterial Spin Labeling to characterize the neural basis of apathy in the major depressive index episode (MDIE), 2) to use an fMRI emotional recognition task (the Variable Attention Affective Task) to characterize apathy involved brain structures dysfunction in the MDIE. 45 subjects will be recruited : i) 15 apathetic subjects with MDIE, ii) 15 non apathetic subjects with MDIE, iii) 15 healthy subjects. This research program was initiatied by the Psychiatry Department of the University Hospital of Rennes and is built on a collaborations between the Psychiatry and Neuroradiology Departments of the University Hospital of Rennes, the URU425 Research Unit and the VisAGeS team. It is funded by the "Fondation de l'Avenir pour la Recherche Médicale Appliquée".