Section: Research Program

Estimation and control for stochastic processes

When one desires to confront theoretical probabilistic models with real data, statistical tools and control of the dynamics are obviously crucial. As matter of course, we develop inference about stochastic processes that we use for modeling, it is the heart of some of our projects. Control of stochastic processes is also a way to optimise administration (dose, frequency) of therapy.

The monograph [81] is a good reference on the basic estimation techniques for diffusion processes. Some attention has been paid recently to the estimation of the coefficients of fractional or multifractional Brownian motion according to a set of observations. Let us quote for instance the nice surveys [48] , [58] . On the other hand, the inference problem for diffusions driven by a fractional Brownian motion has been in its infancy. A good reference on the question is [111] , dealing with some very particular families of equations, which do not cover the cases of interest for us. We also recently proposed least-square estimators for these kind of processes [57] , [98] . Inference about PDMP is also a recent subject that we want to develop. Our team has a good expertise about inference of the rate jump and the kernel of PDMP [46] , [47] , [45] , [33] . However, there is many directions to go further into. For instance, previous works made the assumption of a complete observation of jumps and mode, that is unrealistic in practice. We want to tackle the problem of inference of "Hidden PDMP". It could be also interesting to investigate estimation followed by optimal control for ergodic PDMP. About pharmacokinetics modeling inference, several papers have been reported for the application of system identification techniques. But two issues were ignored in these previous works: presence of timing noise and identification from longitudinal data. In [49] , we have proposed a bounded-error estimation algorithm based on interval analysis to solve the parameter estimation problem while taking into consideration uncertainty on observation time instants. Statistical inference from longitudinal data based on mixed effects models [86] can be performed by the Monolix software (http://www.lixoft.eu/products/monolix/product-monolix-overview/ ) developed by the Monolix group chaired by Marc Lavielle and France Mentré, and supported by Inria. We used it to estimate timor growth in [50] .

We consider the control of stochastic processes within the framework of Markov Decision Processes [100] and their generalization known as multi-player stochastic games [110] , with a particular focus on infinite-horizon problems. In this context, we are interested in the complexity analysis of standard algorithms, as well as the proposition and analysis of numerical approximate schemes for large problems in the spirit of [52] . Regarding complexity, a central topic of research is the analysis of the Policy Iteration algorithm, which has made significant progress in the last years [116] , [99] , [75] , [65] , [109] , but is still not fully understood. For large problems, we have a long experience of sensitivity analysis of approximate dynamic programming algorithms for Markov Decision Processes [107] , [106] , [108] , [88] [13] , and we currently investigate whether/how similar ideas may be adapted to multi-player stochastic games.