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Section: New Software and Platforms

Sam

Keywords: Protein Symmetry Assembly - Protein Docking

Scientific Description

Sam is a program for building models of protein complexes having arbitrary point group symmetry. The Sam program was developed in the frame of the ANR “PEPSI” project with The Nano-D team at Inria Grenoble – Rône Alpes. A journal article describing Sam has been accepted for publication in the Journal of Applied Crystallography [16] .

Functional Description

The underlying approach makes use of multiple one-dimensional polar Fourier correlations (implemented in the Hex code-base) to search rapidly a symmetry-constrained rigid body protein docking search space. The approach may be used to build symmetrical multi-component protein complexes having a given cyclic (Cn), dihedral (Dn), tetrahedral (T), octahedral (O) or icosahedral (I) point group symmetry.