Section: New Software and Platforms

Sam

Keywords: Protein Symmetry Assembly - Protein Docking

Scientific Description

Sam is a program for building models of protein complexes having arbitrary point group symmetry. The Sam program was developed in the frame of the ANR “PEPSI” project with The Nano-D team at Inria Grenoble – Rône Alpes. A journal article describing Sam has been accepted for publication in the Journal of Applied Crystallography [16] .

Functional Description

The underlying approach makes use of multiple one-dimensional polar Fourier correlations (implemented in the Hex code-base) to search rapidly a symmetry-constrained rigid body protein docking search space. The approach may be used to build symmetrical multi-component protein complexes having a given cyclic ($C_n$), dihedral ($D_n$), tetrahedral ($T$), octahedral ($O$) or icosahedral ($I$) point group symmetry.

• Contact: David Ritchie

• URL: http://sam.loria.fr