Section: New Results

Large-Scale Analysis of 3D Protein Interactions

As part of a continuing collaboration with a former doctoral student in the Orpailleur team, Anisah Ghoorah (now at the University of Mauritius), we used her KBDOCK database of all known PPIs to perform a large-scale statistical analysis of the secondary structure composition of known protein-protein binding sites [14] . This showed that some combinations of secondary structure features are significantly favoured, whereas other combinations are considerably dis-favoured. These findings could provide knowledge-based rules for the prediction of unsolved protein-protein interactions.