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Section: Partnerships and Cooperations
National Initiatives
Plan cancer DYNAMO
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Partners - Lab Ampère-Lyon, Lab. Vectorologie et thérapies anticancéreuses- Villejuif and Equipe Inria MONC-Talence
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Coordinator - R. Scorretti, Lab. Ampère / Local coordinator - C. Poignard
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Abstract - Electroporation (EPN) is a method which allows either killing the cells in a target region (tumors) by a nonthermal mechanism (irreversible EPN, or IRE) or allowing non permeant molecules (drugs, DNA) to penetrate the cells. EPN opens new perspectives for cancer treatment (electrochemotherapy, or ECT) and for gene therapy. In spite of its advantages, applications of EPN are still limited because of the scarcity of quantitative data concerning the reaction of tissues following electric pulses. Moreover, due to the lack of reliable tools for treatment planning, most clinical applications deal with superficial tumors in patients treated in more than 130 EU cancer centers using validated standard operating procedures. However the more difficult treatment of deep-seated tumors is still at the stage of academic research and a crucial challenge for forthcoming cancer therapies. This project aims at investigating how EPN can be effectively modeled, from the scale of cell up to the scale of tissue, and how molecular uptake holds and is enhanced by electric field delivery. To develop a dynamic model of tissue EPN, two approaches will be followed: one derived from the macroscopic scale (ad hoc tissue model) and the other from the microscopic scale using homogenization techniques. In order to enable accurate elaboration of the models, experiments will be carried out on raw potato tubers, HEK-293 (Human Embryonic Kidney) cell aggregates and on mice liver and muscle. The transport of molecules through the tissue, which is also a bottleneck, will be overcome thanks to a porous medium approach, which will provide qualitative and quantitative behaviour of the transport in the tissue.
Plan Cancer METASIS
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Team participants - S. Benzekry, Th. Colin, C. Poignard, O. Saut
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Title - Modeling the Interaction of the (Metastasis) Vascular/Tumor Niche Using a Systems Biology Approach
Plan Cancer MIMOSA
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Project acronym - Plan Cancer MIMOSA (Physique, Mathématiques et Sciences de l'ingénieur appliqués au Cancer)
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Team participants - S. Benzekry, Th. Colin, C. Poignard, O. Saut
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Title - Mathematical modeling for exploration of the impact of mechanical constraints on tumor growth
A*Midex MARS
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Partner - Service d'Oncologie Multidisciplinaire & Innovations Thérapeutiques, Hopitaux de Marseille