Section: New Software and Platforms

Totoro & Kotoura

Functional Description

We proposed two methods to decipher the reaction changes during a metabolic transient state using measurements of metabolic concentrations. We called these metabolic hyperstories.

Totoro (for TOpological analysis of Transient metabOlic RespOnse) is based on a qualitative measurement of the concentrations in two steady-states to infer the reaction changes that lead to the observed differences in metabolite pools in both conditions. In the currently available release, a pre-processing and a post-processing steps are included. After the post-processing step, the solutions can be visualised using Dinghy .

Kotoura (for Kantitative analysis Of Transient metabOlic and regUlatory Response And control) infers quantitative changes of the reactions using information on measurement of the metabolite concentrations in two steady-states.

• Participants: Ricardo Andrade, Laurent Bulteau, Louis Duchemin, Alice Julien-Laferrière, Alberto Marchetti-Spaccamela, Arnaud Mary, Vincent Lacroix, Marie-France Sagot, Leen Stougie, Philippe Veber, Susana Vinga

• Contact: Alice Julien-Laferrière, Arnaud Mary, Ricardo Andrade, Marie-France Sagot

• URL: http://hyperstories.gforge.inria.fr/