Section: Application Domains

Health

Cancer diagnostic: from a pool of known genes, the aim is to detect potential mutations that perturb the activity of these genes. Pointing out the right gene helps in prescribing the right drug. The bioinformatics analysis is based on the detection of SNPs (Single Nucleotide Polymorphism) from a set of target genes.

Microbiology: Streptococcus bacteria are considered as major pathogens for humans and lead to many infections. The cause of their pathogenicity can be studied from their genomic structure by comparing different strains. Text of the genomes must first be constructed (assembly process) before to be analyzed (comparative genomic).

HLA genotyping: The human leukocyte antigen (HLA) system drives the regulation of the human immune system. The HLA genes reside on chromosome 6 and have a large number of alleles. Genotyping this group of genes can be done by a deep sequencing of the HLA region, and by comparing reads with a HLA databank (intensive sequence comparison).