Section: Research Program

From geometrical data to multimodal imaging

Brain diseases are associated to alterations of brain structure that can be studied in vivo using anatomical and diffusion MRI. The anatomy of a given subject can be represented by sets of anatomical surfaces (cortical and subcortical surfaces) and curves (white matter tracks) that can be extracted from anatomical and diffusion MRI respectively. We aim to develop approaches that can characterize the variability of brain anatomy within populations of subjects. To that purpose, we propose methods to estimate population atlases that provide an average model of a population of subjects together with a statistical model of their variability. Finally, we aim to introduce representations that can integrate geometrical information (anatomical surfaces, white matter tracts) together with functional (PET, ASL, EEG/MEG) and microstructural information.