Section: New Software and Platforms

Clinica

Keywords: Neuroimaging - Brain MRI - MRI - Clinical analysis - Image analysis - Machine learning

Scientific Description: Clinica is a software platform for multimodal brain image analysis in clinical research studies. It makes it easy to apply advanced analysis tools to large scale clinical studies. For that purpose, it integrates a comprehensive set of processing tools for the main neuroimaging modalities: currently MRI (anatomical, functional, diffusion) and PET, in the future, EEG/MEG. For each modality, Clinica allows to easily extract various types of features (regional measures, parametric maps, surfaces, curves, networks). Such features are then subsequently used as input of machine learning, statistical modeling, morphometry or network analysis methods. Processing pipelines are based on combinations of freely available tools developed by the community. It provides an integrated data management specification to store raw and processing data. Clinica is written in Python. It uses the Nipype system for pipelining. It combines widely-used software for neuroimaging data analysis (SPM, Freesurfer, FSL, MRtrix...), morphometry (Deformetrica), machine learning (Scikit-learn) and the BIDS standard for data organization.

Functional Description: Clinica is a software platform for multimodal brain image analysis in clinical research studies. It makes it easy to apply advanced analysis tools to large scale clinical studies. For that purpose, it integrates a comprehensive set of processing tools for the main neuroimaging modalities: currently MRI (anatomical, functional, diffusion) and PET, in the future, EEG/MEG. For each modality, Clinica allows to easily extract various types of features (regional measures, parametric maps, surfaces, curves, networks). Such features are then subsequently used as input of machine learning, statistical modeling, morphometry or network analysis methods. Clinica also provides an integrated data management specification to store raw and processing data. Overall, Clinica helps to: i) apply advanced analysis tools to clinical research studies, ii) easily share data and results, iii) make research more reproducible.

News Of The Year: - Three clinical studies made with Clinica Clinica : Bertrand et al, JAMA Neurology, 2018 , Jacquemont et al, Neurobiol Aging, 2017, Wen et al, JNNP, 2018 - Clinica presented at OHBM 2018 conference - Clinica was the support for the tutorial "Pattern Recognition for Neuroimaging" at OHBM 2018

• Participants: Jeremy Guillon, Thomas Jacquemont, Pascal Lu, Arnaud Marcoux, Tristan Moreau, Alexandre Routier, Jorge Samper Gonzalez, Junhao Wen, Olivier Colliot, Stanley Durrleman, Michael Bacci, Simona Bottani, Ninon Burgos, Sabrina Fontanella, Pietro Gori, Mauricio Diaz Melo and Elina Thibeau-Sutre

• Partners: Institut du Cerveau et de la Moelle épinière (ICM) - CNRS - INSERM - UPMC

• Contact: Olivier Colliot

• Publications: Amyloidosis and neurodegeneration result in distinct structural connectivity patterns in mild cognitive impairment - Yet Another ADNI Machine Learning Paper? Paving The Way Towards Fully-reproducible Research on Classification of Alzheimer's Disease - Reproducible evaluation of classification methods in Alzheimer's disease: Framework and application to MRI and PET data - Neurite density is reduced in the presymptomatic phase of C9orf72 disease - Early cognitive, structural and microstructural changes in c9orf72 presymptomatic carriers before 40 years of age

• URL: http://www.clinica.run