Section: New Results

Neural correlates of episodic memory in the Memento cohort

Participants : Stéphane Epelbaum [Correspondant] , Vincent Bouteloup, Jean François Mangin, Valentina La Corte, Raffaela Migliaccio, Hugo Bertin, Marie Odile Habert, Clara Fischer, Chabha Azouani, Ludovic Fillon, Marie Chupin, Bruno Vellas, Florence Pasquier, Frederic Blanc, Audrey Gabelle, Mathieu Ceccaldi, Pierre Krolak-Salmon, Jacques Hugon, Olivier Hanon, Olivier Rouaud, Renaud David, Genevieve Chene, Bruno Dubois, Carole Dufouil.

The free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic memory. We investigated the neural correlates of these three memory processes in a large cohort study. The Memento cohort enrolled 2323 outpatients presenting either with subjective cognitive decline or mild cognitive impairment who underwent cognitive, structural MRI and, for a subset, fluorodeoxyglucose-positron emission tomography evaluations. Encoding was associated with a network including parietal and temporal cortices; storage was mainly associated with entorhinal and parahippocampal regions, bilaterally; retrieval was associated with a widespread network encompassing frontal regions. The neural correlates of episodic memory processes can be assessed in large and standardized cohorts of patients at risk for Alzheimer's disease. Their relation to pathophysiological markers of Alzheimer's disease remains to be studied.