Section: Bilateral Contracts and Grants with Industry

Bilateral Grants with Industry

Carthera

Participants : Stéphane Epelbaum [Correspondant] , Alexandre Carpentier, Anne Bertrand, Marie Odile Habert.

• Project title: Open label phase 1/2 study evaluating the safety and usefulness of transient opening of the blood-brain barrier using low intensity pulsed ultrasounds generated by the implantable device SONOCLOUD in patients with mild Alzheimer's disease

• Started in 2016

• Amount: 400 K€

• Coordinator: Stéphane Epelbaum

• Other partners: UPMC, AP-HP

• Abstract: This project aims at opening the blood brain barrier (BBB) in 10 mild Alzheimer's disease patients in order to improve the clearance of beta-amyloid and tau deposits in their brain as suggested in mice models of the disease. This first in man study will evaluate the safety and efficacy of an implanted device, SONOCLOUD, to open the BBB 7 times in each participant. Efficacy will be evaluated on the ability of the method to decrease the amyloid load evidenced by AV45 Positron Emission Tomography (PET), increase the brain metabolism analyzed by Fluorodeoxyglucose PET and improve cognition. If successful, this study will pave the way for future trials in which drugs can be used in addition to BBB opening to maximize their effect.