Section: Partnerships and Cooperations

National Initiatives

ANR

Elker (2017–2020)

Participants : Nacira Abbas, Miguel Couceiro, Amedeo Napoli, Chedy Raïssi.

The objectives of the ELKER ANR Research Project is to study, formalize and implement the search for link keys in RDF data. Link keys generalize database keys in two independent directions, i.e. they deal with RDF data and they apply across two relation datasets. Then we study the automatic discovery of link keys and reasoning with link keys, in taking an FCA point of view. The projects relies on the competencies of Orpailleur in FCA for solving the problem using FCA and pattern structures algorithms, partition pattern structures which are related to the discovery of functional dependencies. This project involves the EPI Orpailleur at Inria Nancy Grand Est, the EPI MOEX at Inria Rhône Alpes, and LIASD at Université Paris 8.

PractiKPharma (2016–2020)

Participants : Adrien Coulet, Joël Legrand, Pierre Monnin, Amedeo Napoli, Malika Smaïl-Tabbone, Yannick Toussaint.

PractiKPharma for “Practice-based evidences for actioning Knowledge in Pharmacogenomics” is an ANR research project (http://practikpharma.loria.fr/) about the validation of domain knowledge in pharmacogenomics. Pharmacogenomics is interested in understanding how genomic variations related to patients have an impact on drug responses. Most of the available knowledge in pharmacogenomics (state of the art) lies in biomedical literature, with various levels of validation. An originality of PractiKPharma is to use Electronic Health Records (EHRs) to constitute cohorts of patients. These cohorts are then mined for extracting potential pharmacogenomics patterns to be then validated w.r.t. literature knowledge for becoming actionable knowledge units. More precisely, firstly we should extract pharmacogenomic patterns from the literature and secondly we should confirm or moderate the interpretation and validation of these units by mining EHRs. Comparing knowledge patterns extracted from the literature with facts extracted from EHRs is a complex task depending on the EHR language –literature is in English whereas EHRs are in French– and on knowledge level, as EHRs represent observations at the patient level whereas literature is related to sets of patients. The PractiKPharma involves three other laboratories, namely LIRMM in Montpellier, SSPIM in St-Etienne and CRC in Paris.

CNRS Mastodons Projects: HyQual, HyQualiBio and QCM-BioChem (2016–2018)

Participants : Nacira Abbas, Guilherme Alves Da Silva, Miguel Couceiro, Alain Gély, Nyoman Juniarta, Tatiana Makhalova, Amedeo Napoli, Chedy Raïssi, Justine Reynaud.

The HyQual project was proposed in 2016 in response to the Mastodons CNRS Call about data quality in data mining (see http://www.cnrs.fr/mi/spip.php?article819&lang=fr). This project is interested in the mining of nutritional data for discovering predictive biomarkers of diabetes and metabolic syndrome in elder populations. The considered data mining methods are hybrid, and they combine symbolic and numerical methods for mining complex and noisy metabolic data [77]. Regarding the mining process, we are interested in the quality of the data at hand and in the discovered patterns. In particular, we check the incompleteness of the data, the quality of the extracted rules and the possible existence of redescriptions.

Initially, the project involved researchers from the EPI Orpailleur, with researchers from LIRIS Lyon, ICube Strasbourg, and INRA Clermont-Ferrand. Then, the project was merged the other Mastodons project named QualiBioConsensus, about the “ranking of biological data using consensus ranking techniques”. The joint Mastodons project was called “HyQualiBio”. The year after, the project was a new time merged with the PEPS Decade project to form the new “QCM-BioChem” (https://www.lri.fr/~cohen/QCM-BioChem.html). The topics of interest for the participants are the mining of complex biological data, rankings and ties in rankings, and the search of dependencies in the web of data.