Section: Application Domains

Tumor growth-oncology

On this topic, we want to propose branching processes to model appearance of mutations in tumor through new collaborations with clinicians. The observed process is the "circulating DNA" (ctDNA). The final purpose is to use ctDNA as a early biomarker of the resistance to an immunotherapy treatment. It is the aim of the ITMO project. Another topic is the identification of dynamic network of expression. In the ongoing work on low-grade gliomas, a local database of 400 patients will be soon available to construct models. We plan to extend it through national and international collaborations (Montpellier CHU, Montreal CRHUM). Our aim is to build a decision-aid tool for personalised medicine. In the same context, there is a topic of clustering analysis of a brain cartography obtained by sensorial simulations during awake surgery.