Section: New Software and Platforms

Totoro & Kotoura

Keywords: Bioinformatics - Graph algorithmics - Systems Biology

Functional Description: Both Totoro and Kotoura decipher the reaction changes during a metabolic transient state, using measurements of metabolic concentrations. These are called metabolic hyperstories. Totoro (for TOpological analysis of Transient metabOlic RespOnse) is based on a qualitative measurement of the concentrations in two steady-states to infer the reaction changes that lead to the observed differences in metabolite pools in both conditions. In the currently available release, a pre-processing and a post-processing steps are included. After the post-processing step, the solutions can be visualised using Dinghy (http://dinghy.gforge.inria.fr). Kotoura (for Kantitative analysis Of Transient metabOlic and regUlatory Response And control) infers quantitative changes of the reactions using information on measurement of the metabolite concentrations in two steady-states.

• Participants: Alice Julien-Laferrière, Ricardo Luiz de Andrade Abrantes, Arnaud Mary, Mariana Ferrarini, Susana Vinga, Irene Ziska and Marie-France Sagot

• Contact: Marie-France Sagot

• URL: http://hyperstories.gforge.inria.fr/