Section: New Results
Deformable Cell Modeling: biomechanics and Liver regeneration
Biomechanically mediated growth control of cancer cells The key intriguing novelty was that the same agent-based model after a single parameter has been calibrated with growth data for multicellular spheroids without application of external mechanical stress by adapting a single parameter, permitted to correctly predict the growth speed of multicellular spheroids of 5 different cell lines subject of external mechanical stress. Hereby the same mechanical growth control stress function was used without any modification . The prediction turned out to be correct independent of the experimental method used to exert the stress, whereby once a mechanical capsule has been used, once dextran has been used in the experiments.
Regeneration of liver with the Deformable Cell Model. The key novelty was the implementation of the model itself, but an interesting novel result is that the DCM permits closure of a pericentral liver lobule lesion generated by drug-induced damage with about 5 times smaller active migration force due to the ability of the cell to strongly deform and squeeze into narrow spaces between the capillaries. This finding stresses that a precise mechanical description is important in view of quantitatively correct modeling results . The deformable cell model however could be used to calibrate the interaction forces of the computationally much cheaper center-based model to arrive at almost the same results.