Section: Partnerships and Cooperations

International Initiatives

Inria Associate Teams Not Involved in an Inria International Labs

NeuroTransSF

• Title: NeuroTransmitter cycle: A Slow-Fast modeling approach

• PI for Inria MathNeuro: Mathieu Desroches

• International Partner (Institution - Laboratory - Researcher):

  • Basque Center for Applied Mathematics (BCAM) (Spain) - Mathematical, Computational and Experimental Neuroscience (MCEN) Team - Serafim Rodrigues

• Start year: 2019

• See also: https://team.inria.fr/neurotranssf/

• This associated team project proposes to deepen the links between two young research groups, on strong Neuroscience thematics. This project aims to start from a joint work in which we could successfully model synaptic transmission delays for both excitatory and inhibitory synapses, matching experimental data, and to supplant it in two distinct directions. On the one hand, by modeling the endocytosis so as to obtain a complete mathematical formulation of the presynaptic neurotransmitter cycle, which will then be integrated within diverse neuron models (in particular interneurons) hence allowing a refined analysis of their excitability and short-term plasticity properties. On the other hand, by modeling the postsynaptic neurotransmitter cycle in link with long-term plasticity and memory. We will incorporate these new models of synapse in different types of neuronal networks and we will then study their excitability, plasticity and synchronisation properties in comparison with classical models. This project will benefit from strong experimental collaborations (UCL, Alicante) and it is coupled to the study of brain pathologies linked with synaptic dysfunctions, in particular certain early signs of Alzheimer's Disease. Our initiative also contains a training aspect with two PhD student involved as well as a series of mini-courses which we will propose to the partner institute on this research topic; we will also organise a "wrap-up" workshop in Sophia at the end of it. Finally, the project is embedded within a strategic tightening of our links with Spain with the objective of pushing towards the creation of a Southern-Europe network for Mathematical, Computational and Experimental Neuroscience, which will serve as a stepping stone in order to extend our influence beyond Europe.

Inria International Partners

Informal International Partners

• VU Amsterdam (Netherlands), Faculty of Science, Mathematics: Daniele Avitabile

• ENS Paris, Laboratoire de Neurosciences Cognitives: Boris Gutkin

• University of the Balearic Islands (Spain), Dept of Applied Mathematics: Antonio Teruel

• Polytechnic University of Catalunya (Spain), Dept of Applied Mathematics: Antoni Guillamon