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DISCO - 2011

Section: Application Domains

Modeling and analysis of Acute Myeolid Leukemia

In collaboration with the BANG project-team at INRIA Paris-Rocquencourt, the DRACULA team at INRIA Grenoble - Rhône-Alpes, the COMMANDS project team at INRIA Saclay-Île-de-France, INSERM, Cordeliers Research Center and St Antoine Hospital, Paris, we consider the modeling and control of Acute Myeloid Leukemia (AML).

The main goal of this project is the theoretical optimization of drug treatments used in AML, with experimental validation in cell cultures, aiming at proposing efficient therapeutic strategies in clinic.

We work on an discrete maturity-structured model of hematopoiesis introduced in [98] . In this model, several generations of cells are considered and, for the first time, the cell cycle duration is assumed to be distributed. At each level, the population of immature cells are divided into two subpopulations: proliferating and non proliferating cells. Physiological phenomena of re-introduction from the non proliferative into the proliferative subpopulation is modeled in the team as a nonlinear dynamical interconnection between the two sub-populations, and input-output tools seem to be useful in this context [35] .