Section: New Results

Yeast comparative genomics

Participants : Pascal Durrens [correspondant] , Tiphaine Martin, David James Sherman.

By using Magnome 's Magus system and YAGA software, we have successfully realized a full annotation and analysis of seven new genomes, provided to the Génolevures Consortium by the CEA–Génoscope (Évry)[15] . Two distant genomes from the Debaryomycetaceae and mitosporic Saccharomycetales clades of the Saccharomycetales were annotated using previously published Génolevures genomes [6] , [10] , [11] as references (in prep.). A further group of five species, comprised of pathogenic and nonpathogenic species, was analyzed with the goal of identifying virulence determinants [37] . By choosing species that are highly related but which differ in the particular traits that are targeted, in this case pathogenicity, we are able to focus of the few hundred genes related to the trait (in rev.). The approximately 40,000 new genes from these studies were classified into existing Génolevures families as well as branch-specific families.

In collaboration with partners in the ISVV, Bordeaux, we have assembled and analyzed 12 wine starter yeasts, with the goal of understanding genetic determinants of performance (in prep.).