Section: Software and Platforms

Pantograph: Inference of metabolic networks

Participants : David James Sherman [correspondant] , Pascal Durrens, Nicolás Loira, Anna Zhukova.

Pantograph is a software tool for inferring whole-genome metabolic models for eukaryote cell factories. It is based on metabolic scaffolds, abstract descriptions of reactions and pathways on which inferred reactions are hung are are eventually connected by an interative mapping and specialization process. Scaffold fragments can be repeatedly used to build specialized subnetworks of the complete model. A novel feature of Pantograph is that it uses expert knowledge implicitly encoded in the scaffold's gene associations, and explicitly transfers this knowledge to the new model. Pantograph is available under an open-source license. For more information see the Pantograph Gforge web site. (http://pathtastic.gforge.inria.fr ).