Section: New Results

Multiple Flexible Protein Structure Alignments

Comparing two or more proteins by optimally aligning and superposing their backbone structures provides a way to detect evolutionary relationships between proteins that cannot be detected by comparing only their primary amino-acid sequences. We have recently extended our “Kpax” protein structure alignment algorithm to flexibly align pairs of structures that cannot be completely superposed by a single rigid-body transformation, and to calculate multiple alignments of several similar structures flexibly. A journal article describing the approach has been published [20].