Section: Partnerships and Cooperations

International Initiatives

Inria Associate Teams Not Involved in an Inria International Labs

Modelling leukemia

• Title: Modeling quiescence and drug resistance in Chronic Myeloid Leukemia

• International Partner (Institution - Laboratory - Researcher):

  • University of Maryland (United States) - Center for Scientific Computation and Mathematical Modeling (CSCAMM) - Levy Doron

• Start year: 2013

• See also: http://dracula.univ-lyon1.fr/modelling_leukemia.php

• Leukemia is the most famous disease of the blood cell formation process (hematopoiesis). Chronic myeloid leukemia results in a uncontrolled proliferation of abnormal blood cells. As the hematopoiesis involves stem cells (not accessible to observations), mathematical modeling is here a great tool to test hypothesis. We will join the expertise of Inria team DRACULA specialized on the modeling of blood cell formation and the Center for Scientific Computation and Applied Mathematical Modeling (CSCAMM, University of Maryland, College Park). The theoretical and modeling experience of team DRACULA and the numerical expertise combined with the links with experimentalists of members of CSCAMM will allow us to study deeply evolution of leukemia. We will especially focus on the behavior of leukemic stem cells and their possibility of becoming quiescent (dormant). Then we will study (using the knowledge obtained on leukemic stem cells) the phenomenon of drug resistance and its propagation over time and finally the mechanisms of multidrug resistance.