Section: Overall Objectives

Overall Applied Objectives

Data are generated in clinical trials or biological experimentations. Our main application of interest is the immune response to vaccine or other immune interventions (such as exogenous cytokines), mainly in the context of HIV infection. The methods developed in this context can be applied in other circumstances but the focus of the team on immunology is important for the relevance of the results and their translation into practice, thanks to a longstanding collaboration with several immunologists and the implication of the team in the Labex Vaccine Research Institute (http://vaccine-research-institute.fr). Exemples of objectives related to this application field are:

• To understand how immune response is generated with immune interventions (vaccines or interleukines)

• To predict what would be the immune response to a given immune intervention for designing next studies and adapting interventions to individual patients