Section: New Results

Analysis of results from Clinical trials and cohorts in HIV

• Bouteloup V, Sabin C, Mocroft A, Gras L, Pantazis N, Le Moing V, d'Arminio Monforte A, Mary-Krause M, Roca B, Miro JM, Battegay M, Brockmeyer N, Berenguer J, Morlat P, Obel N, De Wit S, Fätkenheuer G, Zangerle R, Ghosn J, Pérez-Hoyos S, Campbell M, Prins M, Chêne G, Meyer L, Dorrucci M, Torti C, Thiébaut R; Standard Reference Distribution of CD4 Response to HAART Project Team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. Reference curves for CD4 T-cell count response to combination antiretroviral therapy in HIV-1-infected treatment-naïve patients. HIV Medicine. 2017;18:33-44.

  This is a tool that should help clinicians to evaluate the immunological response to antiretroviral therapy in HIV infected patients. Thanks to the analyse of one of the largest observational database in the world, we provide with an online tool references on the CD4 count during the first year of antiretroviral therapy.

• Picat MQ, Pellegrin I, Bitard J, Wittkop L, Proust-Lima C, Liquet B, Moreau JF, Bonnet F, Blanco P, Thiébaut R; ANRS CO3 Aquitaine Cohort. Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients. PLoS One. 2017;12:e0169164. [25]

  This is an analysis of data on gene expression and factors associated to the immune activation in HIV-infected patients. Using structural models, we disentangle the effect of factors such as CMV and the mediation through type 1 interferon pathway.

• Thiébaut R, Hue S, Le Marec F, Lelièvre JD, Dupon M, Foucat E, Lazaro E, Dabis F, Duffau P, Wittkop L, Surenaud M, Pellegrin I, Lacabaratz C, Bonnet F, Lévy Y; ANRS CO3 Aquitaine Cohort. Serum ST2 level is an independent predictor of all-cause mortality in HIV-infected patients. Aquitaine Cohort, France. AIDS. 2017 [32]

  In this work, we have demonstrated the independent effect of the biomarker ST2 on the overall mortality in a large cohort of HIV infected patients.

• Vladimir Novitsky, Mélanie Prague, Sikhulile Moyo, Tendani Gaolathe, Mompati Mmalane, et al.. High HIV-1 RNA among Newly Diagnosed People in Botswana. AIDS Research and Human Retroviruses, Mary Ann Liebert, To appear.