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  • The Inria's Research Teams produce an annual Activity Report presenting their activities and their results of the year. These reports include the team members, the scientific program, the software developed by the team and the new results of the year. The report also describes the grants, contracts and the activities of dissemination and teaching. Finally, the report gives the list of publications of the year.

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Section: New Results

Multiple Flexible Protein Structure Alignments

Comparing two or more proteins by optimally aligning and superposing their backbone structures provides a way to detect evolutionary relationships between proteins that cannot be detected by comparing only their primary amino-acid sequences. The latest version of our “Kpax” protein structure alignment algorithm can flexibly align pairs of structures that cannot be completely superposed by a single rigid-body transformation, and can calculate multiple alignments of several similar structures flexibly [9]. In collaboration with Alain Hein of the INRA lab “Agronomie et Environnement”, we used Kpax to help study the structures of various “Cyp450” enzymes in plants [81]. In collaboration with Emmanuel Levy of the Weizmann Institute, we used Kpax to superpose and compare all of the symmetrical protein complexes in the Protein Databank in order to verify or remediate their quaternary structure annotations. A manuscript describing this work has been published in Nature Methods [15].