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  • The Inria's Research Teams produce an annual Activity Report presenting their activities and their results of the year. These reports include the team members, the scientific program, the software developed by the team and the new results of the year. The report also describes the grants, contracts and the activities of dissemination and teaching. Finally, the report gives the list of publications of the year.

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Section: Partnerships and Cooperations

National Initiatives

FEDER – SB-Server

Participants : David Ritchie [contact person] , Bernard Maigret, Isaure Chauvot de Beauchêne, Sabeur Aridhi, Marie-Dominique Devignes.

Project title: Structural bioinformatics server; PI: David Ritchie, Capsid (Inria Nancy – Grand Est); Value: 24 k€; Duration: 2015–2020. Description: This funding provides a small high performance computing server for structural bioinformatics research at the Inria Nancy – Grand Est centre.

ANR

Fight-HF

Participants : Marie-Dominique Devignes [contact person] , Malika Smaïl-Tabbone [contact person] , Bernard Maigret, Sabeur Aridhi, Kévin Dalleau, Claire Lacomblez, David Ritchie.

Project title: Combattre l’insuffisance cardiaque; PI: Patrick Rossignol, Univ Lorraine (FHU-Cartage); Partners: multiple; Value: 9 m€ (Capsid and Orpailleur: 450 k€, approx); Duration: 2015–2019. Description: This “Investissements d'Avenir” project aims to discover novel mechanisms for heart failure and to propose decision support for precision medicine. The project has been granted € 9M, and involves many participants from Nancy University Hospital's Federation “CARTAGE” (http://www.fhu-cartage.com/). In collaboration with the Orpailleur Team, Marie-Dominique Devignes is coordinating a work-package on network-based science and drug discovery for this project.

IFB

Participants : Marie-Dominique Devignes [contact person] , Sabeur Aridhi, Isaure Chauvot de Beauchêne, David Ritchie.

Project title: Institut Français de Bioinformatique; PI: Claudine Médigue and Jacques van Helden (CNRS UMS 3601); Partners: multiple; Value: 20 M€ (Capsid: 126 k€); Duration: 2014–2021. Description: The Capsid team is a research node of the IFB (Institut Français de Bioinformatique), the French national network of bioinformatics platforms (http://www.france-bioinformatique.fr). The principal aim is to make bioinformatics skills and resources more accessible to French biology laboratories.

Collaborations with Major European Organizations

  • EBI: European Bioinformatics Institute, Maria Martin team (UK). We are working with the EBI team to validate and improve our graph-based approaches for protein function annotation.

PEPS-INS2I – ORCA 3D

Participants : Isaure Chauvot de Beauchêne [contact person] , Agnibha Chandra, Rohit Roy.

Protect Title: Oligo-RNA Combinatorial Assembly for 3D modeling of protein-RNA complexes. PI: Isaure Chauvot de Beauchêne. Value: 8k€. Description: The project aimed at improving our fragment-based ssRNA docking method, of which we already provided a proof of principle. It mainly provided grants for two internship students to work on (i) a new ssRNA-protein scoring function and (ii) docking with constraints specific to the geometry of ssRNA in RNA loops.