Section: Partnerships and Cooperations

National Initiatives

FEDER – SB-Server

Participants : David Ritchie [contact person] , Bernard Maigret, Isaure Chauvot de Beauchêne, Sabeur Aridhi, Marie-Dominique Devignes.

Project title: Structural bioinformatics server; PI: David Ritchie, Capsid (Inria Nancy – Grand Est); Value: 24 k€; Duration: 2015–2020. Description: This funding provides a small high performance computing server for structural bioinformatics research at the Inria Nancy – Grand Est centre.

ANR

Fight-HF

Participants : Marie-Dominique Devignes [contact person] , Malika Smaïl-Tabbone [contact person] , Bernard Maigret, Sabeur Aridhi, Kévin Dalleau, Claire Lacomblez, David Ritchie.

Project title: Combattre l’insuffisance cardiaque; PI: Patrick Rossignol, Univ Lorraine (FHU-Cartage); Partners: multiple; Value: 9 m€ (Capsid and Orpailleur: 450 k€, approx); Duration: 2015–2019. Description: This “Investissements d'Avenir” project aims to discover novel mechanisms for heart failure and to propose decision support for precision medicine. The project has been granted € 9M, and involves many participants from Nancy University Hospital's Federation “CARTAGE” (http://www.fhu-cartage.com/). In collaboration with the Orpailleur Team, Marie-Dominique Devignes is coordinating a work-package on network-based science and drug discovery for this project.

IFB

Participants : Marie-Dominique Devignes [contact person] , Sabeur Aridhi, Isaure Chauvot de Beauchêne, David Ritchie.

Project title: Institut Français de Bioinformatique; PI: Claudine Médigue and Jacques van Helden (CNRS UMS 3601); Partners: multiple; Value: 20 M€ (Capsid: 126 k€); Duration: 2014–2021. Description: The Capsid team is a research node of the IFB (Institut Français de Bioinformatique), the French national network of bioinformatics platforms (http://www.france-bioinformatique.fr). The principal aim is to make bioinformatics skills and resources more accessible to French biology laboratories.

Collaborations with Major European Organizations

• EBI: European Bioinformatics Institute, Maria Martin team (UK). We are working with the EBI team to validate and improve our graph-based approaches for protein function annotation.

PEPS-INS2I – ORCA 3D

Participants : Isaure Chauvot de Beauchêne [contact person] , Agnibha Chandra, Rohit Roy.

Protect Title: Oligo-RNA Combinatorial Assembly for 3D modeling of protein-RNA complexes. PI: Isaure Chauvot de Beauchêne. Value: 8k€. Description: The project aimed at improving our fragment-based ssRNA docking method, of which we already provided a proof of principle. It mainly provided grants for two internship students to work on (i) a new ssRNA-protein scoring function and (ii) docking with constraints specific to the geometry of ssRNA in RNA loops.