MONC - 2018
Overall Objectives
Bilateral Contracts and Grants with Industry
Overall Objectives
Bilateral Contracts and Grants with Industry


Major publications by the team in recent years
  • 1S. Benzekry, C. Lamont, D. Barbolosi, L. Hlatky, P. Hahnfeldt.

    Mathematical modeling of tumor-tumor distant interactions supports a systemic control of tumor growth, in: Cancer Research, 2017. [ DOI : 10.1158/0008-5472.CAN-17-0564 ]

  • 2S. Benzekry, C. Lamont, A. Beheshti, A. Tracz, J. M. Ebos, L. Haltky, P. Hahnfeldt.

    Classical Mathematical Models for Description and Forecast of Experimental Tumor Growth, in: PLoS Computational Biology, August 2014, vol. 10, no 8, e1003800 p. [ DOI : 10.1371/journal.pcbi.1003800 ]

  • 3S. Benzekry, A. Tracz, M. Mastri, R. Corbelli, D. Barbolosi, J. M. L. Ebos.

    Modeling Spontaneous Metastasis following Surgery: An In Vivo-In Silico Approach, in: Cancer Research, February 2016, vol. 76, no 3, pp. 535 - 547. [ DOI : 10.1158/0008-5472.CAN-15-1389 ]

  • 4D. Bresch, T. Colin, E. Grenier, B. Ribba, O. Saut.

    Computational Modeling Of Solid Tumor Growth: The Avascular Stage, in: SIAM Journal on Scientific Computing, August 2010, vol. 32, no 4, pp. 2321–2344.
  • 5T. Colin, F. Cornelis, J. Jouganous, J. Palussière, O. Saut.

    Patient specific simulation of tumor growth, response to the treatment and relapse of a lung metastasis: a clinical case, in: Journal of Computational Surgery, 2015, 18 p. [ DOI : 10.1186/s40244-014-0014-1 ]

  • 6O. Gallinato, C. Poignard.

    Superconvergent second order Cartesian method for solving free boundary problem for invadopodia formation, in: Journal of Computational Physics, June 2017, vol. 339, pp. 412 - 431. [ DOI : 10.1016/j.jcp.2017.03.010 ]

  • 7D.-C. Imbs, R. El Cheikh, A. Boyer, J. Ciccolini, C. Mascaux, B. Lacarelle, F. Barlesi, D. Barbolosi, S. Benzekry.

    Revisiting bevacizumab + cytotoxics scheduling using mathematical modeling: proof of concept study in experimental non-small cell lung carcinoma, in: CPT: Pharmacometrics and Systems Pharmacology, 2018, pp. 1-9. [ DOI : 10.1002/psp4.12265 ]

  • 8G. Lefebvre, F. Cornelis, P. Cumsille, T. Colin, C. Poignard, O. Saut.

    Spatial modelling of tumour drug resistance: the case of GIST liver metastases Mathematical Medicine and Biology Advance, in: Mathematical Medicine and Biology, 2016, vol. 00, pp. 1 - 26. [ DOI : 10.1093/imammb/dqw002 ]

  • 9M. Leguebe, A. Silve, L. M. Mir, C. Poignard.

    Conducting and permeable states of cell membrane submitted to high voltage pulses: Mathematical and numerical studies validated by the experiments, in: Journal of Theoretical Biology, November 2014, vol. 360, pp. 83-94. [ DOI : 10.1016/j.jtbi.2014.06.027 ]

  • 10F. Raman, E. Scribner, O. Saut, C. Wenger, T. Colin, H. M. Fathallah-Shaykh.

    Computational Trials: Unraveling Motility Phenotypes, Progression Patterns, and Treatment Options for Glioblastoma Multiforme, in: PLoS ONE, January 2016, vol. 11, no 1. [ DOI : 10.1371/journal.pone.0146617 ]

Publications of the year

Articles in International Peer-Reviewed Journals

  • 11A. Andreychenko, B. Denis De Senneville, R. Navest, R. Tijssen, J. Lagendijk, A. Van Den Berg.

    Respiratory motion model based on the noise covariance matrix of a receive array, in: Magnetic Resonance in Medicine, March 2018, vol. 79, no 3, pp. 1730-1735.

  • 12P. Bour, V. Ozenne, F. Marquet, B. Denis De Senneville, E. Dumont, B. Quesson.

    Real-time 3D ultrasound based motion tracking for the treatment of mobile organs with MR-guided high-intensity focused ultrasound, in: International Journal of Hyperthermia, April 2018, vol. 34, no 8, pp. 1225-1235.

  • 13T. Colin, G. Dechristé, J. Fehrenbach, L. Guillaume, V. Lobjois, C. Poignard.

    Experimental estimation of stored stress within spherical microtissues: What can and cannot be inferred from cutting experiments, in: Journal of Mathematical Biology, 2018, vol. 77, no 4.

  • 14A. Collin, S. Imperiale.

    Mathematical analysis and 2-scale convergence of a heterogeneous microscopic bidomain model, in: Mathematical Models and Methods in Applied Sciences, 2018.

  • 15G. Dechristé, J. Fehrenbach, E. Griseti, V. Lobjois, C. Poignard.

    Viscoelastic modeling of the fusion of multicellular tumor spheroids in growth phase, in: Journal of Theoretical Biology, October 2018, vol. 454, pp. 102-109. [ DOI : 10.1016/j.jtbi.2018.05.005 ]

  • 16M. Deville, R. Natalini, C. Poignard.

    A continuum mechanics model of enzyme-based tissue degradation in cancer therapies, in: Bulletin of Mathematical Biology, 2018. [ DOI : 10.1007/s11538-018-0515-2 ]

  • 17C. Ferrer, L. Bartels, M. van Stralen, B. Denis De Senneville, C. T. Moonen, C. Bos.

    Fluid filling of the digestive tract for improved proton resonance frequency shift-based MR thermometry in the pancreas, in: Journal of Magnetic Resonance Imaging, March 2018, vol. 47, no 3, pp. 692-701.

  • 18A. Hocquelet, T. Auriac, C. Perier, C. Dromain, M. Meyer, J.-B. Pinaquy, A. Denys, H. Trillaud, B. Denis De Senneville, V. Vendrely.

    Pre-treatment magnetic resonance-based texture features as potential imaging biomarkers for predicting event free survival in anal cancer treated by chemoradiotherapy, in: European Radiology, July 2018, vol. 28, no 7, pp. 2801-2811. [ DOI : 10.1007/s00330-017-5284-z ]

  • 19D.-C. Imbs, R. El Cheikh, A. Boyer, J. Ciccolini, C. Mascaux, B. Lacarelle, F. Barlesi, D. Barbolosi, S. Benzekry.

    Revisiting bevacizumab + cytotoxics scheduling using mathematical modeling: proof of concept study in experimental non-small cell lung carcinoma, in: CPT: Pharmacometrics and Systems Pharmacology, 2018, pp. 1-9. [ DOI : 10.1002/psp4.12265 ]

  • 20T. Michel, J. Fehrenbach, V. Lobjois, J. Laurent, A. Gomes, T. Colin, C. Poignard.

    Mathematical Modeling of the Proliferation Gradient in MultiCellular Tumor Spheroids, in: Journal of Theoretical Biology, December 2018, vol. 458, pp. 133 - 147. [ DOI : 10.1016/j.jtbi.2018.08.031 ]

  • 21P. Mistani, A. Guittet, C. Poignard, F. Gibou.

    A Parallel Voronoi-Based Approach for Mesoscale Simulations of Cell Aggregate Electropermeabilization, in: Journal of Computational Physics, January 2019, https://arxiv.org/abs/1802.01781 - 21 pages, 16 figures, submitted. [ DOI : 10.1016/j.jcp.2018.12.009 ]

  • 22A. Rodallec, S. Benzekry, B. Lacarelle, J. Ciccolini, R. Fanciullino.

    Pharmacokinetics variability: why nanoparticles are not magic bullets in oncology, in: Critical Reviews in Oncology/Hematology, September 2018, vol. 129, pp. 1 - 12. [ DOI : 10.1016/j.critrevonc.2018.06.008 ]

  • 23A. Rodallec, G. Sicard, R. Fanciullino, S. Benzekry, B. Lacarelle, G. Milano, J. Ciccolini.

    Turning cold tumors into hot tumors: harnessing the potential of tumor immunity using nanoparticles, in: Expert Opinion on Drug Metabolism and Toxicology, October 2018, vol. 14, no 11, pp. 1-9. [ DOI : 10.1080/17425255.2018.1540588 ]

  • 24D. Voyer, A. Silve, L. M. Mir, R. Scorretti, C. Poignard.

    Dynamical modeling of tissue electroporation, in: Bioelectrochemistry, March 2018, vol. 119, pp. 98 - 110. [ DOI : 10.1016/j.bioelechem.2017.08.007 ]

  • 25C. Zhang, A. Collin, P. Moireau, A. Trouvé, M. Rochoux.

    Front shape similarity measure for data-driven simulations of wildland fire spread based on state estimation: Application to the RxCADRE field-scale experiment, in: Proceedings of the Combustion Institute, 2019, vol. 37, no 3, pp. 4201-4209. [ DOI : 10.1016/j.proci.2018.07.112 ]


Invited Conferences

  • 26S. Benzekry.

    Mathematical Modeling and Prediction of Clinical Metastasis, in: Mathematical Challenges in the Analysis of Continuum Models for Cancer Growth, Evolution and Therapy, Oaxaca, Mexico, November 2018.

  • 27S. Benzekry.

    Mathematical Modeling of Tumor-Tumor Distant Interactions Supports a Systemic Control of Tumor Growth, in: 3rd Mathematical Biology Modeling days of Besançon, Besançon, France, June 2018.

  • 28S. Benzekry.

    Mechanistic modeling of metastasis: cancer at the organism scale, in: Mathematical Models in Cancer, Vienna, Austria, July 2018.

  • 29S. Benzekry.

    Optimization of sequential administration of bevacizumab plus cytotoxics in non-small cell lung cancer by combining in vivo experiments and mathematical modeling, in: Mathematical perspectives in the biology and therapeutics of cancer, Marseille, France, July 2018.


Conferences without Proceedings

  • 30P. Bour, V. Ozenne, F. Marquet, B. Denis De Senneville, E. Dumont, B. Quesson.

    Evaluation of 2D simultaneous multi-slice EPI at 1.5T for MR-thermometry in presence of motion, in: International Society of Magnetic Resonance in Medicine, Paris, France, June 2018.

  • 31B. Denis De Senneville, A. Novell, C. J. Arthuis, V. Mendes, P.-A. Dujardin, F. Patat, A. Bouakaz, J.-M. Escoffre, F. Perrotin.

    A fluid dynamic model for quantitative contrast-enhanced ultrasound imaging: validation for the assessment of uteroplacental perfusion, in: IEEE International Ultrasonics Symposium, Kobe, Japan, October 2018.

  • 32A. Gérard, A. Collin, Y. Coudière.

    Validation of a sequential data assimilation method applied to cardiac electrophysiology, in: Virtual Physiological Human conference, Saragosse, Spain, September 2018.

  • 33V. Ozenne, P. Bour, B. Denis De Senneville, M. Delcey, W. Ben Hassen, A. Vaussy, S. Rainer, B. Quesson.

    3D ultrasound based motion tracking combined with rapid multislice MR-thermometry for MR guided HIFU on mobile organs, in: International Society of Magnetic Resonance in Medicine, Paris, France, June 2018.

  • 34C. Zachiu, B. Denis De Senneville, M. Ries, F. Prins, B. Raaymakers.

    Non-rigid CT to MR registration for online external beam radiotherapy guidance, in: 6th MR in RT symposium, Utrecht, Netherlands, June 2018.


Internal Reports

Other Publications

  • 36M. Bilous, C. Serdjebi, A. Boyer, P. Tomasini, C. Pouypoudat, D. Barbolosi, F. Barlesi, F. Chomy, S. Benzekry.

    Computational modeling reveals dynamics of brain metastasis in non-small cell lung cancer and provides a tool for personalized therapy, November 2018, working paper or preprint.

  • 37A. Crombé, C. Perier, M. Kind, B. Denis De Senneville, F. Le Loarer, A. Italiano, X. Buy, O. Saut.

    T2-based MRI Delta-Radiomics Improve Response Prediction in Soft-Tissue Sarcomas Treated by Neoadjuvant Chemotherapy, November 2018, working paper or preprint.

  • 38M. Mastri, C. Perier, G. Macgrogan, J. M. Ebos, S. Benzekry.

    A biologically-based mathematical model for prediction of metastatic relapse, August 2018, 17th Biennial Congress of the Metastasis Research Society, Poster.

  • 39C. Nicolò, M. Mastri, A. Tracz, J. M. Ebos, S. Benzekry.

    Mathematical modeling of differential effects of neo-adjuvant Sunitinib on primary tumor and metastatic growth, April 2018, vol. 78, no 13 Supplement, 4264 p, AACR Annual Meeting 2018, Poster. [ DOI : 10.1158/1538-7445.AM2018-4264 ]

  • 40B. Schneider, A. Boyer, J. Ciccolini, K. Wang, M. E. Fernandez-Zapico, J. Mochel, S. Benzekry.

    Modeling Primary Tumor Dynamics of Human-to-Mouse Xenografted Non-Small Cell Lung Cancer in Response to Administration of Bevacizumab and Pemetrexed-Cisplatin, May 2018, Population Approach Group in Europe (PAGE) Meeting 2018, Poster.

  • 41C. Vaghi, A. Rodallec, R. Fanciullino, J. Ciccolini, C. Poignard, S. Benzekry.

    Improving the efficacy of anti-cancer nanoparticles with data-driven mathematical modeling, June 2018, Data Science Summer School, Poster.