Section: New Results
T2‐based MRI Delta‐radiomics improve response prediction in soft‐tissue sarcomas treated by neoadjuvant chemotherapy
Authors: Amandine Crombé, MS Cynthia Périer, Michèle Kind, Baudouin Denis De Senneville, François Le Loarer, Antoine Italiano, Xavier Buy, Olivier Saut. Paper published in the Journal of Magnetic Resonance Imaging. https://hal.inria.fr/hal-01929807
Background: Standard of care for patients with high‐grade soft‐tissue sarcoma (STS) are being redefined since neoadjuvant chemotherapy (NAC) has demonstrated a positive effect on patients' outcome. Yet response evaluation in clinical trials still relies on RECIST criteria.
Purpose: To investigate the added value of a Delta‐radiomics approach for early response prediction in patients with STS undergoing NAC.
Study Type: Retrospective.
Population: Sixty‐five adult patients with newly‐diagnosed, locally‐advanced, histologically proven high‐grade STS of trunk and extremities. All were treated by anthracycline‐based NAC followed by surgery and had available MRI at baseline and after two chemotherapy cycles.
Field Strength/Sequence: Pre‐ and postcontrast enhanced T1‐weighted imaging (T1‐WI), turbo spin echo T2‐WI at 1.5 T.
Assessment: A threshold of
Statistical Tests: Classification models based on logistic regression, support vector machine, k‐nearest neighbors, and random forests were elaborated using crossvalidation (training and validation) on 50 patients ("training cohort") and was validated on 15 other patients ("test cohort").
Results: Sixteen patients were good‐HR. Neither RECIST status (P = 0.112) nor semantic radiological variables were associated with response (range of P‐values: 0.134–0.490) except an edema decrease (P = 0.003), although 14 shape and texture features were (range of P‐values: 0.002–0.037). On the training cohort, the highest diagnostic performances were obtained with random forests built on three features:
Data Conclusion: A T2‐based Delta‐radiomics approach might improve early response assessment in STS patients with a limited number of features.