DRACULA - 2019 - Annual activity report

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DRACULA

DRACULA - 2019

Project-Team Dracula

Team, Visitors, External Collaborators

Overall Objectives

Research Program

New Software and Platforms

CelDyn

New Results

Mathematical models describing the interaction between cancer and immune cells in the lymph node
WASABI: a dynamic iterative framework for gene regulatory network inference
A multiscale model of platelet-fibrin thrombus growth in the flow
Mathematical modeling of platelet production
Nonlinear analysis of a model for yeast cell communication
Alzheimer’s disease and prion: An in vitro mathematical model
Calibration, Selection and Identifiability Analysis of a Mathematical Model of the in vitro Erythropoiesis in Normal and Perturbed Contexts
Model-based assessment of the role of uneven partitioning of molecular content on heterogeneity and regulation of differentiation in CD8 T-cell immune responses
Spatial lymphocyte dynamics in lymph nodes predicts the cytotoxic T-Cell frequency needed for HIV infection control
Drugs modulating stochastic gene expression affect the erythroid differentiation process
Stochastic gene expression with a multistate promoter: breaking down exact distributions
Cell generation dynamics underlying naive T-cell homeostasis in adult humans
Erythroid differentiation displays a peak of energy consumption concomitant with glycolytic metabolism rearrangements

Partnerships and Cooperations

Dissemination

Bibliography

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Section: Partnerships and Cooperations

National Initiatives

ANR

ANR SinCity “Single cell transcriptomics on genealogically identified differentiating cells” (https://anr.fr/Projet-ANR-17-CE12-0031), 2017-2020.

Participant : Olivier Gandrillon [Coordinator] .
Olivier Gandrillon participates in the ANR MEMOIRE (head Jacqueline Marvel) dedicated to “MultiscalE MOdeling of CD8 T cell Immune REsponses”, 2018-2021.

Other projects

Thomas Lepoutre is a member of the ERC MESOPROBIO (head Vincent Calvez) dedicated to "Mesoscopic models for propagation in biology", 2015-2020: (http://vcalvez.perso.math.cnrs.fr/mesoprobio.html).

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