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Section: Partnerships and Cooperations
International Initiatives
Inria Associate Teams Not Involved in an Inria International Labs
MathModelingHematopoiesis
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Title: Mathematical modeling of hematopoietic stem cell dynamics in normal and pathological hematopoiesis with optimal control for drug therapy
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International Partner (Institution - Laboratory - Researcher):
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The project proposes to develop and analyse new mathematical models of Hematopoietic Stem Cell population dynamics in normal and pathological hematopoiesis. Two important questions will be explored in this project: i) the biological data concerning the hematopoiesis process evolves constantly, and new understanding modifies the established mathematical models, ii) modeling constraints us to simplify the complicated biological scenarios, which moving away from the reality, but enabling us to reach a certain comprehension of the hematopoiesis process.
The project will shed new light on the different physiological mechanisms that converge toward the continuous regeneration of blood cells, for example: the behavior of hematopoietic stem cells under stress conditions, the understanding of deregulation of erythropoiesis under drug treatments (this can lead to lack of red blood cells (anemia), or a surplus of red blood cells (erythrocytoses)), the appearance of oscillations in patients with Chronic Myeloid Leukemia (CML); Or, the overproduction of blasts in patients with Acute Myeloid Leukemia (AML)). The effect of the immune system and drug therapy in the presence of CML or AML will be included in the model and optimal control method will also be used.