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Section: Partnerships and Cooperations
International Initiatives
Inria Associate Teams Not Involved in an Inria International Labs
ToFMod
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Title: Cardiac Biomechanical Modeling of Chronic Right Ventricular Loading
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International Partner (Institution - Laboratory - Researcher):
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This collaboration aims at addressing a crucial issue in cardiology of congenital heart diseases, namely, the optimal timing of pulmonary valve replacement (PVR) in patients with surgically repaired tetralogy of Fallot (ToF) prone to chronic pulmonary regurgitation or right ventricular outflow tract stenosis. Our strategy consists in exploiting the predictive power of biomechanical modeling to shed light in the decision process. We will start by a detailed proof-of-concept study, based on datasets that will be acquired in patients indicated for percutaneous PVR, prior to the procedure, and in the follow-up at 3- and 12-months post-PVR. These datasets will be first used to calibrate the Inria M3DISIM patient-specific heart model simulating a cardiac cycle (at each follow-up time point) to access the myocardial properties – namely, the active contractility and passive stiffness. The instantaneous tissue properties will be statistically analyzed and compared with the level of reverse remodeling – i.e. the positive outcome of PVR. Secondly, the data at each time point will be used to calibrate and further develop the models of long-term tissue remodeling created by the M3DISIM researchers. It is only by combining such invaluable longitudinal data with biomechanical modeling expertise that progress can be achieved in the above objective, indeed.