Section: Partnerships and Cooperations

International Initiatives

Inria International Labs

Inria@SiliconValley

Associate Team involved in the International Lab:

Snowball

• Title: Discovering knowledge on drug response variability by mining electronic health records

• International Partner (Institution - Laboratory - Researcher):

  • University of Stanford (United States) - Department of Medicine, Stanford Center for Biomedical Informatics Research (BMIR) - Nigam Shah

• Start year: 2017

• See also: http://snowball.loria.fr/

• Snowball (2017-2019) is an Inria Associate Team and the continuation of the preceding Associate Team called Snowflake (2014-2016). The objective of Snowball is to study drug response variability through the lens of Electronic Health Records (EHRs). This is motivated by the fact that many factors, genetic as well as environmental, contribute to different responses from people to the same drug. The mining of EHRs can bring substantial elements for understanding and explaining drug response variability.

  Accordingly the objectives of Snowball are to identify in EHR repositories groups of patients which are responding differently to similar treatments, and then to characterize these groups and predict patient drug sensitivity. These objectives are complementary to those of the PractiKPharma ANR project. Moreover, Adrien Coulet finished in September 2019 a two-years sabbatical stay in the lab of Nigam Shah at Stanford University initiated in September 2017 (and partly granted by an “Inria délégation”).

Informal International Partners: Research Collaboration with HSE Moscow

Participants : Alexandre Bazin, Nacira Abbas, Guilherme Alves Da Silva, Miguel Couceiro, Nyoman Juniarta, Tatiana Makhalova, Amedeo Napoli, Justine Reynaud.

An ongoing collaboration involves the Orpailleur team and Sergei O. Kuznetsov at Higher School of Economics in Moscow (HSE). Amedeo Napoli visited HSE laboratory several times while Sergei O. Kuznetsov visits Inria Nancy Grand Est every year. The collaboration is materialized by the joint supervision of students (such as the thesis of Aleksey Buzmakov defended in 2015 and the ongoing thesis of Tatiana Makhalova), and the the organization of scientific events, as the workshop FCA4AI with seven editions between 2012 and 2019 (see http://www.fca4ai.hse.ru).

This year, we participated in the writing of common publications around the thesis work of Tatiana Makhalova and the organization of one main event, namely the seventh edition of the FCA4AI workshop in August 2019 at the IJCAI Conference which was held in Macao China.