Section: Application Domains

Prion.

[In collaboration with M. Doumic (INRIA Rocq.), P. Gabriel and B. Perthame (Paris 6) – ANR TOPPAZ]

We study mathematically and numerically the polymerization/fragmentation equation involved in prion aggregation. We have investigated first the case of a size-dependent polymerization rate motivated by recent experiments. We now focus on some issue in optimization of protocol. This is closely related to recent challenges in fitness optimization, and optimal control.