Section: New Results

Novel mathematical model of Adipose tissue cells size distribution

HA Soula (Beagle) C. Soulage, A Géloën (CARMEN)

We present a novel model to explain bimodality of size distribution of adipocytes: adipose tissue cells. These cells are dedicated to storing energy excess in form of fat and therefore can experience wide variations of sizes. Ubiquitous to all the species, we tested so far the size distributions are bimodal with no characteristic size. Using data from experiments, we provide a simple surface based model of circulating fats that cells can exchange. We show that in the physiological range for the parameters of the model, we obtain bimodal distribution. We also provide prediction of the size evolution during severe caloric restriction that we were able to verify experimentally as well.