Section: New Results

Coding isoform structures

Our researches on gene isoform structures started in 2014 with the CG-Alcode Associated Team and in collaboration with Anne Bergeron from the LACIM (Montréal, Canada). We aimed at defining better definitions of isoform orthology at the coding level, which are based on the preservation of all the exon junctions in two orthologous isoforms. This estimation is achieved at the gene level, where sequence homology is detected for both exons and their flanking intronic splice sites [19]. The approach largely outperforms competing programs in terms of precision and recall. Using the successive releases of the ten years old CCDS database, we show that the discovery rate of orthologous isoforms between human and mouse is growing continuously and that it displays no sign of completion.