Section: New Software and Platforms


Keywords: Systems Biology - Bioinformatics - Genomics - Gene regulatory networks

Functional Description

Pantograph is a software toolbox to reconstruct, curate and validate genome-scale metabolic models. It uses existing metabolic models as templates, to start its reconstructions process, to which new, species-specific reactions are added. Pantograph uses an iterative approach to improve reconstructed models, facilitating manual curation and comparisons between reconstructed model's predictions and experimental evidence.

Pantograph uses a consensus procedure to infer relationships between metabolic models, based on several sources of orthology between genomes. This allows for a very detailed rewriting of reaction's genome associations between template models and the model you want to reconstruct.