Section: Bilateral Contracts and Grants with Industry

Bilateral grants with industry

Fourmentin-Guilbert Foundation: Macromolecule detection in cryo electron tomograms

Participants: Emmanuel Moebel, Charles Kervrann.

Collaborator: Damien Larivière (Fourmentin-Guilbert Foundation).

The Fourmentin-Guilbert Foundation strives for building a virtual E. coli bacteria. Information about the position of macromolecules within the cell is necessary to achieve such a 3D molecularly-detailed model. The Fourmentin-Guilbert Foundation supports cutting-edge in-situ cryo electron tomography combined with image processing at the Max-Planck Institute of Biochemistry to map the spatial distribution of the ribosomes, and obtain structural information on the complexes they form in-situ with cofactors and other ribosomes. The objective of the project is to explore and evaluate novel methods from the field of 3D shape retrieval for identifying, localizing and counting macromolecules (e.g., 70S ribosome) within a tomogram. This project is also supported by “Region Bretagne”.