Section: New Software and Platforms


GrAPFI: Graph-based Automatic Protein Function Inference

Keyword: Proteins

Functional Description: GrAPFI is a Graph-based Automatic Protein Function Inference tool that aims to annotate protein sequences with EC numbers. The underlying philosophy of GrAPFI assumes that proteins can be linked through the domains, families, and superfamilies that they share. Several domain databases exist such as e.g. Pfam, SMART, CDD, Gene3D, and Prosite. Furthermore, InterPro aims to integrate information from all such databases by assigning them unique InterPro signatures. GrAPFI tool also shares Interpro signatures, as it includes information from several major family and domain databases. Our computational analysis and cross-validation show that GrAPFI achieves state-of-the-art performance in EC number prediction.