Section: New Software and Platforms

IRENA

Numerical Assessment of IRreversible Electroporation ablation

Keywords: Cancer - Numerical electroporation

Scientific Description: The C++ software IRENA developed by O. Gallinato and C. Poignard within the Inria team Monc enable sto compute the static electric field distribution in the clinical configuration of IRE ablation of liver tumors. The code is based on the finite volume method on Cartesian grid. The needles and the liver boundary are determined as the zero of a level-set function. Close to the boundaries, the first and second order derivatives are computed with the standard Ghost Fluid Method. The equivalent conductivities at half points are computed thanks to harmonic mean (additivity law of resistivity). In order to maintain a reasonable computation time, the refinement is low enough (1 mm3 grid voxels). As the mesh does not pick up the very fine needles, the Dirichlet conditions imposed on the active parts of the electrodes and the Neumann conditions imposed on the insulated parts are changed into Robin conditions on the first layer of points around the needles, thanks to a second order development. This results in a numerical scheme, which is computationally efficient and accurate enough.

Functional Description: Digital simulation tool for the assessment of irreversible electroporation clinical process

• Authors: Olivier Gallinato and Clair Poignard

• Contact: Clair Poignard