Section: New Software and Platforms


GP progression model

Keywords: Data modeling - Data visualization - Data integration - Machine learning - Biostatistics - Statistical modeling - Medical applications - Evolution - Brain - Uncertainly - Uncertainty quantification - Alzheimer's disease - Probability - Stochastic models - Stochastic process - Trajectory Modeling - Marker selection - Health - Statistic analysis - Statistics - Bayesian estimation

Functional Description: Disease progression modeling (DPM) of Alzheimer's disease (AD) aims at revealing long term pathological trajectories from short term clinical data. Along with the ability of providing a data-driven description of the natural evolution of the pathology, DPM has the potential of representing a valuable clinical instrument for automatic diagnosis, by explicitly describing the biomarker transition from normal to pathological stages along the disease time axis.

In this software we reformulate DPM within a probabilistic setting to quantify the diagnostic uncertainty of individual disease severity in an hypothetical clinical scenario, with respect to missing measurements, biomarkers, and follow-up information. The proposed formulation of DPM provides a statistical reference for the accurate probabilistic assessment of the pathological stage of de-novo individuals, and represents a valuable instrument for quantifying the variability and the diagnostic value of biomarkers across disease stages.

This software is based on the publication:

Probabilistic disease progression modeling to characterize diagnostic uncertainty: Application to staging and prediction in Alzheimer's disease. Marco Lorenzi, Maurizio Filippone, Daniel C. Alexander, Sebastien Ourselin Neuroimage. 2019 Apr 15,190:56-68. doi: 10.1016/j.neuroimage.2017.08.059. Epub 2017 Oct 24. HAL Id : hal-01617750 https://hal.archives-ouvertes.fr/hal-01617750/

Release Functional Description: - New interface and output - Completely based on pytorch