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OPIS - 2019

Overall Objectives
New Software and Platforms
New Results
Bilateral Contracts and Grants with Industry

Section: Application Domains

Image restoration for two-photon microscopy

Participants: Emilie Chouzenoux, Jean-Christophe Pesquet, Mathieu Chalvidal (Collaboration: Claire Lefort, XLIM, CNRS, Limoges)

Through an ongoing collaboration with physicists from XLIM laboratory (CNRS, Limoges, France), we propose advanced mathematical and computational solutions for multiphoton microscopy (MPM) 3D image restoration. This modality enjoys many benefits such as a decrease in phototoxicity and increase in penetration depth. However, blur and noise issues can be more severe than with standard confocal images. Our objective is to drastically improve the quality of the generated images and their resolution by improving the characterization of the PSF of the system [12] and compensating its effect. We consider the application of the improved MPM imaging tool to the microscopic analysis of muscle ultrastructure and composition, with the aim to help diagnosing muscle disorders including rare and orphan muscle pathologies.