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  • We continued the activity developed on bioinformatics puzzles by our two-months exhibition in 2010 at Palais de la découverte (science museum in Paris). These “puzzles du génome” explain the basics of sequence assembly, RNA secondary structures and phylogenetic reconstruction http://www.lifl.fr/~giraud/puzzles . In 2012, we demonstrated these puzzles to more than 150 high schools pupils (J.F. Berthelot, S. Blanquart, M. Giraud, M. Salson, A. Thomas, M. Pupin).