Section: New Results

High-throughput V(D)J repertoire analysis

High-throughput V(D)J repertoire analysis is an activity started in the group in 2012. As mentioned in previous reports, we produced a platform dedicated to analysing lymphocyte populations: Vidjil. Starting from DNA sequences, Vidjil is able to identify and quantify lymphocyte populations, visualise them and store metadata. Vidjil is now used routinely in Lille hospital and is also tested in other laboratories around the world.

With collaborators in Prague we used Vidjil in a retrospective study on patients suffering acute lymphoblastic leukemia [3] . The study identified a new measure of predicting relapse in patients, just a month after the diagnosis. This measure is simple as it relies on the diversity of the lymphocyte population.