Section: New Software and Platforms

QuantEv

Keywords: Photonic imaging - Fluorescence microscopy - Biomedical imaging - Image analysis - Image sequence - Statistic analysis

Functional Description: The QUANTEV software analyzes the spatial distribution of intracellular events represented by any static or dynamical descriptor, provided that the descriptors are associated with spatial coordinates. QUANTEV first computes 3D histograms of descriptors in a cylindrical coordinate system with computational cell shape normalization, enabling comparisons between cells of different shape. Densities are obtained via adaptive kernel density estimation, and we use the Circular Earth Mover’s Distance to measure the dissimilarity between densities associated to different experimental conditions. A statistical analysis on these distances reliably takes into account the biological variability over replicated experiments.

• Participants: Jean Salamero, Jérôme Boulanger and Liu Zengzhen

• Partner: UMR 144 CNRS - Institut Curie

• Contact: Charles Kervrann

• Publication: QuantEv: quantifying the spatial distribution of intracellular events

• URL: http://mobyle-serpico.rennes.inria.fr/cgi-bin/portal.py#forms::QuantEv-Densities