Section: New Results

Annotation of the OC43 coronavirus genome

OC43 coronavirus is recognized as frequent cause of respiratory infection. We have conducted a bioinformatics study of 8 coronavirus genomes collected from patients at Lille hospital : gene annotation, phylogenetic analysis and amino acids substitutions. Several genotypes (B, E, F and G) were identified and two clusters of patients were defined from chronological data and phylogenetic trees based on the genomic sequences,. Analyses of amino acids substitutions of the S protein sequences identify substitutions specific of genotype F strains circulating among French people. This work is a collaboration with Anne Goffard (CHRU Lille and CIIL).