Section: New Results

Nonribosomal peptides

Norine is a comprehensive public database for non-ribosomal peptides developed by the team for more than 10 years. The Norine database quality has been enhanced through a semi-automatic curation process of data. Particularly, more than 500 SMILES annotations have been added or updated. This allowed us to check and correct the monomeric graphs, i.e. a 2D representation of the monomeric composition of the NRPs, thanks to dedicated tools like Smiles2Monomers. This update was done in collaboration with members of the Proteome Informatics Group from SIB (Swiss Institute of Bioinformatics). New annotations on monoisotopic mass and molecular formulas have also been added. The Norine interface was improved and new features are available, such as the possibility to access the complete change history of each entry. To encourage new submissions of NRPs, authors of new NRPs are now visible as contributors on Norine home page. Finally, we published this year, in the field of biocontrol (a contraction of “biological control”), a paper on bioinformatic tools for the discovery of new lipopeptides [5], essentially based on the Norine platform.